Respiratory and Meningeal Pathogens Research Unit

Publications (2007 - July 2008)

Journal Articles

1. Farrell DJ, Klugman KP, Pichichero M (2007) Increased antimicrobial resistance among nonvaccine serotypes of Streptococcus pneumoniae in the pediatric population after the introduction of 7-valent pneumococcal vaccine in the United States Pediatr Infect Dis J; 26: 123 - 128.
2. Madhi SA, Adrian P, Kuwanda L, Jassat W, Jones S, Little T, Soininen A, Cutland C, Klugman KP (2007) Long-term immunogenicity and efficacy of a 9-valent conjugate pneumococcal vaccine in human immunodeficient virus infected and non-infected children in the absence of a booster dose of vaccine. Vaccine; 25: 2451 - 2457.
3. Vaughan DJ, Tillotson GS, Klugman KP (2007) Streptococcus pneumoniae: review of factors relevant to development and management of fluoroquinolone resistance in the nursing home setting. Infect Dis Clin Pract; 15: 92 - 99.
4. Anderson R, Steel HC, Cockeran R, Smith A, von Gottberg A, de Gouveia L, Brink A, Klugman KP, Mitchell TJ, Feldman C (2007) Clarithromycin alone and in combination with ceftriaxone inhibits the production of pneumolysin by both macrolide - susceptible and macrolide - resistant strains of Streptococcus pneumoniae. J Antimicrob Chemother; 59: 224-9.
5. Rozen DE, McGee L, Levin BR, Klugman KP (2007) The fitness costs of fluoroquinolone resistance in Streptococcus pneumoniae. Antimicrob Agents Chemother, 51: 412 - 416.
6. Klugman KP, Madhi SA, Feldman C (2007) HIV and pneumococcal disease. Curr Opinion Infect Dis; 20: 11 - 15.
7. Klugman KP (2007) Clinical impact of antibiotic resistance in respiratory tract infections. Int J Antimicrob Agents; 29 Suppl 1: S6 - S10.
8. Coulson GB, von Gottberg A, du Plessis M, Smith AM, de Gouveia L, Klugman KP for the Group for Enteric, Respiratory and Meningeal Disease Surveillance in South Africa (GERMS-SA) (2007) Meningococcal disease in South Africa 1999 - 2002. Emerg Infect Dis; 13: 273 - 281.
9. Wolter N, Smith AM, Low DE, Klugman KP (2007) High level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae. Antimicrob Agents Chemother; 51: 1092 -1095.
10. Madhi SA, Klugman KP (2007) World health organization definition of “radiologically - confirmed pneumonia” may underestimate the true public health value of conjugate pneumococcal vaccines. Vaccine; 25: 2413 - 2419.
11. Siber GR, Chang IH, Baker S, Fernsten P, O’Brien KL, Santosham M, Klugman KP, Madhi SA, Paradiso P, Kohberger R (2007) Estimating the protective concentration of anti-pneumococcal capsular polysaccharide antibodies. Vaccine; 25: 3816 - 3826.
12. Klugman KP, Madhi SA (2007) Pneumococcal vaccines and flu preparedness. Science; 316: 49 - 50.
13. Feldman C, Klugman KP, Yu VL, Ortqvist A, Chiou CCC, Chedid MBF, Rello J, Wagener M and the International Pneumococcal Study Group (2007) Bacteremic pneumococcal pneumonia: impact of HIV on clinical presentation and outcome. J Infect; 55: 125 - 135.
14. Madhi SA, Ludwig H, Kuwanda L, van Niekerk N, Cutland C, Klugman, KP (2007) Seasonality, incidence and repeat human metapneumovirus lower respiratory tract infections in an area with a high prevalence of human immunodeficiency virus type-1 infection. Pediatr Infect Dis J; 26: 693 - 699.
15. Yu V,  Hansen DS, Ko WC, Sagnimeni A, Klugman KP, von Gottberg A, Goossens H, Wagener MM, , Benedi VJ, International Klebsiella Study Group (2007) Virulence characteristics of Klebsiella and clinical manifestations of  K. pneumoniae bloodstream infections. Emerg Infect Dis; 13: 986 - 993.
16. Albrich WC, Madhi SA, Lafond KE, Klugman KP (2007) Herd immunity after pneumococcal conjugate vaccination. Lancet; 370: 218 - 219.
17. Schentag JJ, Klugman KP, Yu VL, Adelman MH,  Wilton GJ, Chiou CC, Patel M, Lavin B, Paladino JA (2007) Streptococcus pneumoniae bactaeremia: pharmacodynamic correlations with outcome and macrolide resistance - a controlled study. Int J Antimicrob Agents; 30: 264 - 269.
18. Alanee SRJ, McGee L, Jackson D, Chiou CC, Feldman C, Morris AJ, Ortqvist A, Rello J, Luna CM, Baddour LM, Ip M, Yu VL, Klugman KP  for the International Pneumococcal Study Group (2007)  Association of serotypes of Streptococcus pneumoniae with disease severity and outcome in adults: an international study. Clin Infect Dis; 45: 46 - 51.
19. Madhi SA, Adrian P, Kuwanda L, Cutland C, Albrich W,  Klugman KP (2007) Long-term effect of pneumococcal conjugate vaccine on nasopharyngeal colonization by Streptococcus pneumoniae and associated interactions with Staphylococcus aureus and Haemophilus influenzae colonization in HIV infected and HIV uninfected children. J Infect Dis; 196: 1662-1666
20. Anderson R, Steel HC, Cockeran R, von Gottberg A, de Gouveia L, Klugman KP, Mitchell TJ, Feldman C (2007) Comparison of the effects of macrolides, amoxicillin, ceftriaxone, doxycycline, tobramycin, and fluoroquinolones on the production of pneumolysin by Streptococcus pneumoniae in vitro. J Antimicrob Chemother; 60: 1155 - 1158.
21. Pipingas A, Dangor Y, Radebe F, Fehler HG, Khumalo S, de Gouveia L, Koornhof, HJ, Ballard, RC (2007) Microbiological investigation of Bartholin's gland abscesses in urban women in Johannesburg. Southern Afr J Epidemiol Infect; 22: 18 - 22.
22. Madhi SA, Ludewick H, Kuwanda L, van Niekerk N, Cutland C, Klugman KP (2007) Epidemiology of severe human metapneumovirus lower respiratory tract infection in an area with a high prevalence of human immunodeficiency virus type-1 infection. Pediatr Infect Dis J; 26: 693 - 699.
23. Klugman KP (2007) Risk factors for antibiotic resistance in Streptococcus pneumoniae. South Afr Med J; 97:1129 - 1132
24. Geddes AM, Klugman KP, Rolinson GN (2007) Introduction: historical perspective and development of  amoxicillin/clavulanate. Int J Antimicrob Agents, 25 Sep 2007
25. Cherian T for Expert Committee (includes KP Klugman, Co-chair) (2007) WHO expert consultation on serotype composition of pneumococcal conjugate vaccines for use in resource-poor developing countries, 26-27 October 2006, Geneva: Meeting Report. Vaccine; 25: 6557 - 6564.
26. Pemba L, Charalambous S, von Gottberg A, Magadla B, Moloi V, Seabi O, Wasas A, Klugman KP, Chaisson RE, Fielding K, Churchyard GJ, Grant AD. Impact of cotrimoxazole on non-susceptibility to antibiotics in Streptococcus pneumoniae carriage isolates among HIV-infected mineworkers in South Africa. J Infect. 2008 ;56: 171 - 178.
27. Klugman KP. Risk factors for antibiotic resistance in Streptococcus pneumoniae. S Afr Med J. 2007; 97:1129 - 1132.
28. Wolter N, Smith AM, Farrell DJ, Northwood JB, Douthwaite S, Klugman KP. Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation. Antimicrob Agents Chemother 2008; 52: 435 - 440.
29. Madhi SA, Albrich W. WHO guidelines for treatment of severe pneumonia. Lancet. 2007; 370(9585): 386 - 387.
30. von Gottberg A, du Plessis M, Cohen C, Prentice E, Schrag S, de Gouveia L, Coulson G, de Jong G, Klugman KP; Group for Enteric, Respiratory and Meningeal Disease Surveillance in South Africa. Emergence of endemic serogroup W135 meningococcal disease associated with a high mortality rate in South Africa. Clin Infect Dis. 2008; 46: 377 - 386.
31. von Gottberg A, Klugman KP, Cohen C, Wolter N, de Gouveia L, du Plessis M, Mpembe R, Quan V, Whitelaw A, Hoffmann R, Govender N, Meiring S, Smith AM, Schrag S; Group for Enteric, Respiratory and Meningeal Disease Surveillance in South Africa (GERMS-SA). Emergence of levofloxacin-non-susceptible Streptococcus pneumoniae and treatment for multidrug-resistant tuberculosis in children in South Africa: a cohort observational surveillance study. Lancet 2008; 371(9618): 1108 - 1113.
32. Wolter N, von Gottberg A, du Plessis M, de Gouveia L, Klugman KP; for the Group for Enteric, Respiratory and Meningeal Disease Surveillance in South Africa (GERMS-SA). Molecular basis and clonal nature of increasing pneumococcal macrolide resistance in South Africa, 2000-2005. Int J Antimicrob Agents 2008; 32: 62 - 67.
33. Madhi SA, Levine OS, Hajjeh R, Mansoor OD, Cherian T. Vaccines to prevent pneumonia and improve child survival. Bull World Health Organ. 2008; 86: 365 - 372.
34. Edginton ME, Rakgokong L, Verver S, Madhi SA, Koornhof HJ, Wong ML, Hodkinson HJ. Tuberculosis culture testing at a tertiary care hospital: options for improved management and use for treatment decisions. Int J Tuberc Lung Dis. 2008; 12: 786 - 791.
35. Cooper PA, Madhi SA, Huebner RE, Mbelle N, Karim SS, Kleinschmidt I, Forrest BD, Klugman KP. Apnea and its possible relationship to immunization in ex-premature infants. Vaccine. 2008; 26: 3410 - 3413.
36. Klugman KP, Walsh AL, Phiri A, Molyneux EM. Mortality in penicillin-resistant pneumococcal meningitis. Pediatr Infect Dis J. 2008; 27: 671 - 672.