Oesophageal Cancer Research Unit

Publications

1. Dandara, C., Ballo, R., and Parker M.I. (2005).  CYP3A5 Genotypes and Risk of Oesophageal Cancer in Two South African Populations. Cancer Letters, 225, 275 – 282.
2. Li, D-P,  Dandara, D., and  Parker M.I.  (2005). Association of cytochrome P450 2E1 genetic polymorphisms with squamous cell carcinoma of the oesophagus Clin. Chem. Lab. Med.  43, 370 – 375.
3. Ndlovu, M., Leaner, V.D. and Parker, M.I.  (2005).  Methylation of the Alpha2(1) Procollagen Promoter Inhibits Gene Expression in SV40-Transformed Fibroblasts.  SA Journal Science 101, 187 - 192
4. Leaner, V.,  M.R., Masemola, A. and Parker, M.I. (2005).   Species Specific Regulation of the a2(1) Procollagen Gene by proximal Promoter Elements.  IUBMB-Life, 57, 363 – 369.
5. Dandara, C., LI, D-P., Walther, G., and Parker, M.I. (2006).  Gene-Environment Interaction: The Role of SULT1A1 and CYP3A5 Polymorphisms as Risk Modifiers for Squamous Cell Carcinoma of the Oesophagus.  Carcinogenesis, 27, 791 - 797.
6. Wang, B., Hendricks. D., Wamunyokoli, F. and Parker, M.I. (2006).The GROα/CXCR2 and GROβ/CXCR2 Autocrine Loops Contribute to Cellular Proliferation in Oesophageal Cancer. Cancer Research,  66, 3071 - 3077.
7. Leaner, V. and Parker. M.I. (2006). Phosphorylation of the alpha 2(1)  Procollagen Promoter Binding Proteins is Required for Promoter Activity.  IUBMB-Life, 58, 97 – 102.
8. Huajian T., Davis, E., Abrahams, A., Mowla, S., Parker M.I. and Prince, S.  (2007) A Role for Tbx2 in the Regulation of the a2(1) Collagen Gene in Human Fibroblasts. J. Cell. Biochem, 102, 618-625
9.  Fong, S.F.T., He, Q-P,  Dietzsch, E. Asunction, L,. Hollosi, P., Parker, M.I. and Csiszar, K. (2007). Lysyl-Oxidase-like-2 Expression is Increased in Colon and Esophageal Tumors and Associated with Less Differentiated Colon Tumors.  Genes Chromosomes and Cancer, 46, 644 - 655.
10. Matsha, T., Donninger, H., Erasmus, RT, Hendricks, D, Stepien, A. and Parker, MI. (2007). Expression of p53 and its Homolog, p73, in HPV DNA Positive Oesophageal Squamous Cell Carcinomas.  Virology, 369, 182 - 190
11. Davis, E., Teng, H., Parker, M.I., Goding, C. and Prince, S.  (2008). Re-Expression of TBX2 in a Transformed Human Fibroblast Cell Line Blocks Cells in Mitosis, Resulting in Decreased Proliferation.  Oncogene, 27, 976 – 984.
12. Copley, L., van der Watt, P.,  Wirtz, K.W.,  Parker, M.I. and Leaner, V.D. (2008). Photolon™, a chlorin e6 derivative, triggers ROS production and light- dependent cell death via necrosis.  Int. J. Biochem. & Cell Biol. 40, 227-35.
13. Donninger, H, Binder, A, Bohm, L and Parker, MI. (2008). Differential Effects of Novel Tumour- Derived p53 Mutations on the Transformation of NIH 3T3 Cells. Biol. Chem, 389, 57-67.
14. Abrahams, A, Mowla, S, Parker, M.I., Goding, C.R. and Prince, S.  (2008). UV Mediated Regulation of the Anti-Senescence Factor, Tbx2.  J. Biol. Chem. 283, 2223 - 2230.  
15. Li, D-P, Dandara, C., Walther, G,  and Parker, M.I. (2008). Genetic polymorphisms of alcohol metabolizing enzymes: their role in susceptibility to oesophageal cancer. Clin. Chem. Lab. Med. 46, 323- 328.
16. Teng, H., Parker, M.I. and Prince, S. (2008). Functional characterization of cis-acting elements involved in basal transcription of the human Tbx2 gene: A new insight into the role of Sp1 in transcriptional regulation. Gene, 423, 8 – 13.
17. Hunter, R.,Kaschula, C.H,  Parker, M.I. Caira, M.R., Richards, P.,  Travis, S.,Taute, F. and Qwebani, T. (2008). Substituted ajoenes as novel anti-cancer agents Bioorg. Med. Chem. Lett. 18, 5277 – 5279.
18. van der Watt PJ,  Maske CP, Hendricks DT, Parker MI, Denny L, Govender D, Birrer MJ, Leaner, VD. (2009). The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation. Int J Cancer. 124,1829-1840.
19. Wang, B, Khachigian, LM,  Birrer, MJ, Esau, L, Zhou, X. Parker, MI and Hendricks, DT.  (2009). A key role for mediating and Maintaining GRO/CXCR2 proliferative signalling in oesophageal cancer. Mol. Cancer. Res. 5; 755-764
20. Suvi Torniainen, M. Iqbal Parker, Ville Holmberg, Elisa Lahtela,Collet Dandara, Irma Jarvela (2009). Screening of variants for lactase persistence/non-persistence in   populations from South Africa and Ghana. BMC Genetics 10; 1-5
21. Abrahams A, Parker M.I.  and Prince S. (2009). The T-box transcription factor Tbx2:Its role in development and possible implication in cancer. IUBMB-Life (In Press)
22. Kaschula, C, Hunter, R and Parker, MI (2009). The anti-cancer activity of ajoene: the use of chemically synthesised stable analogues.  Biofactors, In Press
23. Li, D-P.,  Dandara, C., Walther, G. and Parker, M.I. Genetic Polymorphisms in the Glutathione S-Transferase Genes (GSTM1, T1 & P1) and Oesophageal Cancer Susceptibility (Manuscript Submitted