Molecular Mycobacteriology Research Unit

Papers

1. Warner, D.F. and Mizrahi, V. 2012. Tuberculosis Drug Discovery: Target Identification and Validation. In: Drug Discovery in Africa (Chibale, K.C., Davies-Coleman, M. & Masimerembwa, C., eds.), Springer, In press.
2. Ahmadou Ahidjo, B., Kuhnert, D., McKenzie, J., Machowski, E.E., Gordhan, B.G., Arcus, V.L., Abrahams, G.L., and Mizrahi, V. 2011. VapC toxins from Mycobacterium tuberculosis are ribonucleases that inhibit mycobacterial growth and are neutralized by cognate VapB antitoxins. PLoS One 6:e21738.
3. Warner, D.F., and Mizrahi, V. 2011. How Mycobacteria Make Ends Meet. Mol. Microbiol. 79:283-287 [Invited MicroCommentary]
4. Williams, M.J., Kana, B.D., and Mizrahi, V. 2011. Functional analysis of molybdopterin biosynthesis in mycobacteria identifies a novel fused molybdopterin synthase in Mycobacterium tuberculosis. J. Bacteriol. 193:98-106
5. Kana, B.D., and Mizrahi, V. 2010. Resuscitation-promoting factors in bacterial population dynamics during TB infection. Drug Discovery Today: Disease Mechanisms 7(1):e13-e18.
6. Warner D.F. 2010. The role of DNA repair in M. tuberculosis pathogenesis. Drug Discov. Today Dis. Mech. 7:e5-e11.
7. Kana, B.D. and Mizrahi, V. 2010. Resuscitation promoting factors as lytic enzymes for bacterial growth and signaling. FEMS Immunol. Med. Microbiol. 58:39-50.
8. Kana, B.D., Abrahams, G.L., Sung, N., Warner, D.F., Gordhan, B.G., Machowski, E.E. Tsenova, L., Sacchettini, J.C., Stoker, N.G., Kaplan, G., and Mizrahi, V. 2010. Role of the Y-family DNA polymerase-encoding DinB homologs, Rv1537 and Rv3056 in Mycobacterium tuberculosis. J. Bacteriol. 192:2220-2227.
9. Ioerger, T., Feng, Y., Ganesula, K., Cheng, X., Dobos, K.M., Fortune, S., Jacobs, W.R., Jr., Mizrahi, V., Parish, T., Rubin, E., Sassetti, C., and Sacchettini, J.C. 2010. Variation among genome sequences of H37Rv strains of M. tuberculosis from multiple laboratories. J. Bacteriol. 192:3645-3653.
10. Kana, B.D., Mizrahi, V., and Gordhan, B.G. 2010. Depletion of resuscitation promoting factors has limited impact on the drug susceptibility of Mycobacterium tuberculosis. J. Antimicrob. Chemother. 65:1583-1585.
11. Warner, D.F., Ndwandwe, D.E., Abrahams, G.L., Kana, B.D., Venclovas, Č., and Mizrahi, V. 2010. Essential roles for imuA’ and imuB-encoded accessory factors in DnaE2-dependent mutagenesis in mycobacteria. Proc. Natl. Acad. Sci. USA 107:13093-13098.
12. Mowa MB, Warner DF, Kaplan G, Kana BD, Mizrahi, V. 2009. Function and regulation of class I ribonucleotide reductase-encoding genes. J. Bacteriol. 191:985-995.
13. Kana, B. D., Machowski, E.E., Schechter, N., Shin, J.-T., Rubin, H., and Mizrahi, V. 2009. Electron transport and respiration. In: Mycobacterium: Genomics and Molecular Biology (Parish, T. & Brown, A., eds.), Horizon Press, London, ch. 3, p. 35-64.
14. Savvi SS, Warner DF, Mizrahi V, and Dawes SS. 2008. Functional characterization of a vitamin B12-dependent methylmalonyl pathway in Mycobacterium tuberculosis: Implications for propionate metabolism during growth on fatty acids. J. Bacteriol. 190:3886-3895.
15. Kana BD, Gordhan BG, Downing KJ, Sung N, Vostroktunova G, Machowski EE, Tsenova G, Young M, Kaprelyants A, Kaplan G, and Mizrahi V. 2008. The resuscitation-promoting factors of Mycobacterium tuberculosis are required for virulence and resuscitation from dormancy but are collectively dispensable for growth in vitro. Mol. Microbiol. 67:672-684
16. Wang XM, Galamba A, Warner DF, Soetaert K, Merkel J, Kalai M, Bafani P, Lefevre P, Mizrahi V, and Content J. 2008. IS1096-mediated rearrangements play a key role on genome evolution of Mycobacterium smegmatis. Tuberculosis 88:399-409
17. Warner DF, and Mizrahi V. 2008. M. tuberculosis physiology. In: Handbook of Tuberculosis: Molecular Biology and Biochemistry (S.H.E. Kaufmann & E.J. Rubin, eds.), WILEY-VCH, Weinheim, Germany, ch. 3, pp. 53-69.
18. Warner DF, Savvi SS, Mizrahi V, and Dawes SS. 2007. A riboswitch regulates expression of the coenzyme B12-independent methionine synthase in Mycobacterium tuberculosis: implications for differential methionine synthase function in strains H37Rv and CDC1551. J. Bacteriol. 189:3655-3659.
19. Warner DF, and Mizrahi V. 2007. The survival kit of Mycobacterium tuberculosis. Nat. Med. 13:282-284.
20. Machowski EE, Barichievy S, Springer B, Durbach SI, and Mizrahi V. 2007. In vitro analysis of rates and spectra of mutations in a polymorphic region of the Rv1046 PE_PGRS gene of Mycobacterium tuberculosis. J. Bacteriol. 189:2190-2195
21. Warner DF, Mizrahi V. (2006) Tuberculosis chemotherapy: the influence of bacillary stress and damage response pathways on drug efficacy. Clin Microbiol Rev. 19(3):558-70.
22. Cholo MC, Boshoff HI, Steel HC, Cockeran R, Matlola NM, Downing KJ, Mizrahi V, Anderson R. (2006) Effects of clofazimine on potassium uptake by a Trk-deletion mutant of Mycobacterium tuberculosis. J Antimicrob Chemother. 57(1):79-84.
23. Gordhan BG, Smith DA, Kana BD, Bancroft G, Mizrahi V. (2006) The carbon starvation-inducible genes Rv2557 and Rv2558 of Mycobacterium tuberculosis are not required for long-term survival under carbon starvation and for virulence in SCID mice. Tuberculosis (Edinb). 86:430-437
24. Warner DF, Etienne G, Wang XM, Matsoso LG, Dawes SS, Soetaert K, Stoker NG, Content J, Mizrahi V. (2006) A derivative of Mycobacterium smegmatis mc2155 that lacks the duplicated chromosomal region. Tuberculosis (Edinb). 86:438-444
25. Shi L, Sohaskey CD, Kana BD, Dawes S, North RJ, Mizrahi V, Gennaro ML. (2005) Changes in energy metabolism of Mycobacterium tuberculosis in mouse lung and under in vitro conditions affecting aerobic respiration. Proc Natl Acad Sci U S A. 102(43):15629-34.
26. Matsoso LG, Kana BD, Crellin PK, Lea-Smith DJ, Pelosi A, Powell D, Dawes SS, Rubin H, Coppel RL, Mizrahi V. (2005) Function of the cytochrome bc1-aa3 branch of the respiratory network in mycobacteria and network adaptation occurring in response to its disruption. J Bacteriol. 187(18):6300-8.
27. Downing KJ, Mischenko VV, Shleeva MO, Young DI, Young M, Kaprelyants AS, Apt AS, Mizrahi V. (2005) Mutants of Mycobacterium tuberculosis lacking three of the five rpf-like genes are defective for growth in vivo and for resuscitation in vitro. Infect Immun. 73(5):3038-43.
28. Machowski, E.E., Dawes, S.S. and Mizrahi, V. (2005). TB tools to tell the tale - molecular genetic methods for mycobacterial research. Int. J. Biochem. Cell Biol. 37:54-68.
29. Mizrahi, V., Buckstein, M. and Rubin, H. (2005). Nucleic Acid metabolism, ch. 23, p. 369-378. In: Tuberculosis and the Tubercle Bacillus. (Cole, S.T., McMurray, D., Gicquel, B., and Jacobs, W.R., Jr, eds), American Society for Microbiology Press, Washington, D.C.