Centre for Molecular and Cellular Biology

Publications

2009

• Abdallah Abdallah M, Verboom Theo, Weerdenburg Eveline M, Gey van Pittius Nicolaas C, Mahasha Phetole W, Jiménez Connie, Parra Marcela, Cadieux Nathalie, Brennan Michael J, Appelmelk Ben J and Bitter Wilbert. (2009) PPE and PE_PGRS proteins of Mycobacterium marinum are transported via the type VII secretion system ESX-5. Mol Microbiol 73:329-40.
• Andersen Paal Skytt, Havndrup Ole, Hougs Lotte, Sørensen Karina M, Jensen Morten, Larsen Lars Allan, Hedley Paula, Thomsen Alex Rojas Bie, Moolman-Smook Johanna, Christiansen Michael and Bundgaard Henning. (2009) Diagnostic yield, interpretation, and clinical utility of mutation screening of sarcomere encoding genes in Danish hypertrophic cardiomyopathy patients and relatives. Hum Mutat 30:363-70.
• Bardien Soraya, Human Hannique, Harris Tashneem, Hefke Gwynneth, Veikondis Rene, Schaaf H Simon, van der Merwe Lize, Greinwald John H, Fagan Johan and de Jong Greetje. (2009) A rapid method for detection of five known mutations associated with aminoglycoside-induced deafness. BMC Med Genet 10:2.
• Bardien Soraya, Keyser Rowena, Yako Yandiswa, Lombard Debbie and Carr Jonathan. (2009) Molecular analysis of the parkin gene in South African patients diagnosed with Parkinson's disease. Parkinsonism Relat Disord 15:116-21.
• Bezuidenhout Juanita, Roberts Teri, Muller Liesel, van Helden Paul and Walzl Gerhard. (2009) Pleural tuberculosis in patients with early HIV infection is associated with increased TNF-alpha expression and necrosis in granulomas. PLoS One 4:e4228.
• Black Gillian F, Thiel Bonnie A, Ota Martin O, Parida Shreemanta K, Adegbola Richard, Boom W Henry, Dockrell Hazel M, Franken Kees L M C, Friggen Annemiek H, Hill Philip C, Klein Michel R, Lalor Maeve K, Mayanja Harriet, Schoolnik Gary, Stanley Kim, Weldingh Karin, Kaufmann Stefan H E, Walzl Gerhard, Ottenhoff Tom H M and GCGH Biomarkers for TB Consortium. (2009) Immunogenicity of novel DosR regulon-encoded candidate antigens of Mycobacterium tuberculosis in three high-burden populations in Africa. Clin Vaccine Immunol 16:1203-12.
• Brink P A, Moolman-Smook J C and Corfield V A. (2009) Mendelian-inherited heart disease: a gateway to understanding mechanisms in heart disease Update on work done at the University of Stellenbosch. Cardiovasc J Afr 20:57-63.
• Chegou Novel N, Black Gillian F, Kidd Martin, van Helden Paul D and Walzl Gerhard. (2009) Host markers in QuantiFERON supernatants differentiate active TB from latent TB infection: preliminary report. BMC Pulm Med 9:21.
• Detjen A K, Loebenberg L, Grewal H M S, Stanley K, Gutschmidt A, Kruger C, Du Plessis N, Kidd M, Beyers N, Walzl G and Hesseling A C. (2009) Short-term reproducibility of a commercial interferon gamma release assay. Clin Vaccine Immunol 16:1170-5.
• Diacon Andreas H, Pym Alexander, Grobusch Martin, Patientia Ramonde, Rustomjee Roxana, Page-Shipp Liesl, Pistorius Christoffel, Krause Rene, Bogoshi Mampedi, Churchyard Gavin, Venter Amour, Allen Jenny, Palomino Juan Carlos, De Marez Tine, van Heeswijk Rolf P G, Lounis Nacer, Meyvisch Paul, Verbeeck Johan, Parys Wim, de Beule Karel, Andries Koen and Mc Neeley David F. (2009) The diarylquinoline TMC207 for multidrug-resistant tuberculosis. N Engl J Med 360:2397-405.
• Djoba Siawaya J F, Beyers N, van Helden P and Walzl G. (2009) Differential cytokine secretion and early treatment response in patients with pulmonary tuberculosis. Clin Exp Immunol 156:69-77.
• Djoba Siawaya Joel Fleury, Chegou Novel N, van den Heuvel Michel M, Diacon Andreas H, Beyers Nulda, van Helden Paul and Walzl Gerhard. (2009) Differential cytokine/chemokines and KL-6 profiles in patients with different forms of tuberculosis. Cytokine 47:132-6.
• Donald Peter R and van Helden Paul D. (2009) The global burden of tuberculosis--combating drug resistance in difficult times. N Engl J Med 360:2393-5.
• Hayward Don, van Helden Paul D and Wiid Ian J F. (2009) Glutamine synthetase sequence evolution in the mycobacteria and their use as molecular markers for Actinobacteria speciation. BMC Evol Biol 9:48.
• Human H, Lombard D, de Jong G and Bardien S. (2009) A South African family with the mitochondrial A1555G mutation on haplogroup L0d. Biochem Biophys Res Commun 382:390-4.
• Laigaard Jennie, Pedersen Nina Gros, Larsen Severin Olesen, Hedley Paula Louise, Wøjdemann Karen, Gjerris Anne Cathrine, Shalmi Anne-Cathrine, Sundberg Karin, Tabor Ann and Christiansen Michael. (2009) ADAM12 in first trimester maternal serum from pregnancies conceived by assisted reproduction techniques (ART). Prenat Diagn 29:628-9.
• Louw G E, Warren R M, Gey van Pittius N C, McEvoy C R E, Van Helden P D and Victor T C. (2009) A balancing act: Efflux/influx in mycobacterial drug resistance. Antimicrob Agents Chemother.
• Louw G E, Warren R M, van Pittius N C Gey, McEvoy C R E, Van Helden P D and Victor T C. (2009) A balancing act: efflux/influx in mycobacterial drug resistance. Antimicrob Agents Chemother 53:3181-9.
• Louw Gail E, Warren Robin M, van Helden Paul D and Victor Thomas C. (2009) Rv2629 191A/C nucleotide change is not associated with rifampicin resistance in Mycobacterium tuberculosis. Clin Chem Lab Med 47:500-1.
• Marais B J, Hesseling A C, Schaaf H S, Gie R P, van Helden P D and Warren R M. (2009) Mycobacterium tuberculosis transmission is not related to household genotype in a setting of high endemicity. J Clin Microbiol 47:1338-43.
• Marais Ben J, Parker Sarah K, Verver S, van Rie A and Warren R M. (2009) Primary and postprimary or reactivation tuberculosis: time to revise confusing terminology? AJR Am J Roentgenol 192:W198; author reply W199-200.
• Marcotty T, Matthys F, Godfroid J, Rigouts L, Ameni G, van Pittius N Gey, Kazwala R, Muma J, van Helden P, Walravens K, de Klerk L M, Geoghegan C, Mbotha D, Otte M, Amenu K, Abu Samra N, Botha C, Ekron M, Jenkins A, Jori F, Kriek N, McCrindle C, Michel A, Morar D, Roger F, Thys E and van den Bossche P. (2009) Zoonotic tuberculosis and brucellosis in Africa: neglected zoonoses or minor public-health issues? The outcomes of a multi-disciplinary workshop. Ann Trop Med Parasitol 103:401-11.
• McEvoy C R E, Warren R M and van Helden PD. (2009) Molecular methods and their application in TB epidemiology.. In: Tuberculosis.. pp: 28-37. eds Schaaf H S and Zumla A L, Elsevier.
• McIlleron Helen, Willemse Marianne, Werely Cedric J, Hussey Gregory D, Schaaf H Simon, Smith Peter J and Donald Peter R. (2009) Isoniazid plasma concentrations in a cohort of South African children with tuberculosis: implications for international pediatric dosing guidelines. Clin Infect Dis 48:1547-53.
• Michel A L, Coetzee M L, Keet D F, Maré L, Warren R, Cooper D, Bengis R G, Kremer K and van Helden P. (2009) Molecular epidemiology of Mycobacterium bovis isolates from free-ranging wildlife in South African game reserves. Vet Microbiol 133:335-43.
• Möller Marlo, Nebel Almut, Valentonyte Ruta, van Helden Paul D, Schreiber Stefan and Hoal Eileen G. (2009) Investigation of chromosome 17 candidate genes in susceptibility to TB in a South African population. Tuberculosis (Edinb) 89:189-94.
• Müller Borna, Hilty Markus, Berg Stefan, Garcia-Pelayo M Carmen, Dale James, Boschiroli M Laura, Cadmus Simeon, Naré Bongo, Ngandolo Richard, Godreuil Sylvain, Diguimbaye-Djaibé Colette, Kazwala Rudovick, Bonfoh Bassirou, Njanpop-Lafourcade Betty M, Sahraoui Naima, Guetarni Djamel, Aseffa Abraham, Mekonnen Meseret H, Rasolofo Razanamparany Voahangy, Ramarokoto Herimanana, Djønne Berit, Oloya James, Machado Adelina, Mucavele Custodia, Skjerve Eystein, Portaels Francoise, Rigouts Leen, Michel Anita, Müller Annélle, Källenius Gunilla, van Helden Paul D, Hewinson R Glyn, Zinsstag Jakob, Gordon Stephen V and Smith Noel H. (2009) African 1; An Epidemiologically Important Clonal Complex of Mycobacterium bovis Dominant in Mali, Nigeria, Cameroon and Chad. J Bacteriol 191:1951-60.
• Nusbaum Chad, Ohsumi Toshiro K, Gomez James, Aquadro John, Victor Thomas C, Warren Robert M, Hung Deborah T, Birren Bruce W, Lander Eric S and Jaffe David B. (2009) Sensitive, specific polymorphism discovery in bacteria using massively parallel sequencing. Nat Methods 6:67-9.
• Ronacher Katharina, Hadley Katie, Avenant Chanel, Stubsrud Elisabeth, Simons S Stoney Jr, Louw Ann and Hapgood Janet P. (2009) Ligand-selective transactivation and transrepression via the glucocorticoid receptor: role of cofactor interaction. Mol Cell Endocrinol 299:219-31.
• Uys Pieter W, van Helden Paul D and Hargrove John W. (2009) Tuberculosis reinfection rate as a proportion of total infection rate correlates with the logarithm of the incidence rate: a mathematical model. J R Soc Interface 6:11-15.
• Uys Pieter W, Warren Robin, van Helden Paul D, Murray Megan and Victor Thomas C. (2009) Potential of rapid diagnosis for controlling drug-susceptible and drug-resistant tuberculosis in communities where Mycobacterium tuberculosis infections are highly prevalent. J Clin Microbiol 47:1484-90.
• van der Spuy G D, Kremer K, Ndabambi S L, Beyers N, Dunbar R, Marais B J, van Helden P D and Warren R M. (2009) Changing Mycobacterium tuberculosis population highlights clade-specific pathogenic characteristics. Tuberculosis (Edinb) 89:120-5.
• van der Spuy G D, van Helden P D and Warren R M. (2009) Effect of study duration on the interpretation of tuberculosis molecular epidemiology investigations. Tuberculosis (Edinb) 89:238-42.
• van der Spuy G D, Warren R M and van Helden P D. (2009) The role of molecular epidemiology in low-income, high-burden countries. Int J Tuberc Lung Dis 13:419-20.
• Vivier Johannes, Bardien Soraya, Van der Merwe Lize, Brusnicky Jeanette, Zaharie Dan, Keyser Rowena, Hewlett Richard, de Jong Greetje and Hartzenberg Bennie. (2009) A study of meningiomas in South Africa: investigating a correlation between clinical presentation, histopathology and genetic markers. Br J Neurosurg 23:63-70.
• Warren R M, Streicher E M, van Pittius N C Gey, Marais B J, van der Spuy G D, Victor T C, Sirgel F, Donald P R and van Helden P D. (2009) The clinical relevance of Mycobacterial pharmacogenetics. Tuberculosis (Edinb) 89:199-202.

2008

• Andersen Paal Skytt, Havndrup Ole, Hougs Lotte, Sørensen Karina M, Jensen Morten, Larsen Lars Allan, Hedley Paula, Bie Thomsen Alex Rojas, Moolman-Smook Johanna, Christiansen Michael and Bundgaard Henning. (2008) Diagnostic yield, interpretation, and clinical utility of mutation screening of sarcomere encoding genes in Danish hypertrophic cardiomyopathy patients and relatives. Hum Mutat.
• Ang C F, Ong C S, Rukmana A, Pham Thi K L, Yap S F, Ngeow Y F, Ho M L, Sudiro T M, Bela B, Jordaan A M, Streicher E M and Victor T C. (2008) An overview of the phenotypic and genotypic characteristics of multidrug-resistant Mycobacterium tuberculosis isolates from four Asian countries. J Med Microbiol 57:1039-40.
• Carroll N M, Uys P, Hesseling A, Lawrence K, Pheiffer C, Salker F, Duncan K, Beyers N and van Helden P D. (2008) Prediction of delayed treatment response in pulmonary tuberculosis: Use of time to positivity values of Bactec cultures. Tuberculosis (Edinb) epub.
• Charalambous S, Grant A D, Moloi V, Warren R, Day J H, van Helden P, Hayes R J, Fielding K L, De Cock K M, Chaisson R E and Churchyard G J. (2008) Contribution of reinfection to recurrent tuberculosis in South African gold miners. Int J Tuberc Lung Dis 12:942-8.
• Chege Gerald K, Warren Robin M, van Pittius Nico C Gey, Burgers Wendy A, Wilkinson Robert J, Shephard Enid G and Williamson Anna-Lise. (2008) Detection of natural infection with Mycobacterium intracellulare in healthy wild-caught Chacma baboons (Papio ursinus) by ESAT-6 and CFP-10 IFN-gamma ELISPOT tests following a tuberculosis outbreak. BMC Microbiol 8:27.
• Chegou Novel N, Walzl Gerhard, Bolliger Chris T, Diacon Andreas H and van den Heuvel Michel M. (2008) Evaluation of Adapted Whole-Blood Interferon-gamma Release Assays for the Diagnosis of Pleural Tuberculosis. Respiration 76(2):131-8.
• Chibi Moredreck, Meyer Mervin, Skepu Amanda, G Rees D Jasper, Moolman-Smook Johanna C and Pugh David J R. (2008) RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1. J Mol Biol 384:908-16.
• Cooke Graham S, Campbell Sarah J, Bennett Steve, Lienhardt Christian, McAdam Keith Pwj, Sow Oumou, Gustafson Per, Mwangulu Frank, van Helden Paul, Fine Paul, Hoal Eileen G and Hill Adrian V. (2008) Mapping of a Novel Susceptibility Locus Suggests a Role for MC3R and CTSZ in Human Tuberculosis. Am J Respir Crit Care Med 178(2):203-7.
• Djoba Siawaya Joel Fleury, Bapela Nchinya Bennedict, Ronacher Katharina, Veenstra Hanne, Kidd Martin, Gie Robert, Beyers Nulda, van Helden Paul and Walzl Gerhard. (2008) Immune parameters as markers of tuberculosis extent of disease and early prediction of anti-tuberculosis chemotherapy response. J Infect 56:340-7.
• Djoba Siawaya Joel Fleury, Roberts Teri, Babb Chantal, Black Gillian, Golakai Hawa Jande, Stanley Kim, Bapela Nchinya Bennedict, Hoal Eileen, Parida Shreemanta, van Helden Paul and Walzl Gerhard. (2008) An evaluation of commercial fluorescent bead-based luminex cytokine assays. PLoS ONE 3:e2535.
• Djoba Siawaya Joel Fleury, Bapela Nchinya Bennedict, Ronacher Katherina, Veenstra Hanne, Kidd Martin, Gie Robert, Beyers Nulda, van Helden Paul and Walzl Gerhard. (2008) Immune parameters as markers of tuberculosis extent of disease and early prediction of anti-tuberculosis chemotherapy response. J Infect 56(5):340-7.
• Flashman E, Korkie L, Watkins H, Redwood C and Moolman-Smook J C. (2008) Support for a trimeric collar of myosin binding protein C in cardiac and fast skeletal muscle, but not in slow skeletal muscle. FEBS Lett 582:434-8.
• Gibson Andrea L, Huard Richard C, Gey van Pittius Nicolaas C, Lazzarini Luiz Claudio Oliveira, Driscoll Jeffrey, Kurepina Natalia, Zozio Thierry, Sola Christophe, Spindola Silvana Miranda, Kritski Afrânio L, Fitzgerald Daniel, Kremer Kristin, Mardassi Helmi, Chitale Poonam, Brinkworth Jessica, Garcia de Viedma Dario, Gicquel Brigitte, Pape Jean W, van Soolingen Dick, Kreiswirth Barry N, Warren Robin M, van Helden Paul D, Rastogi Nalin, Suffys Philip N, Lapa e Silva Jose and Ho John L. (2008) Application of sensitive and specific molecular methods to uncover global dissemination of the major RDRio Sublineage of the Latin American-Mediterranean Mycobacterium tuberculosis spoligotype family. J Clin Microbiol 46:1259-67.
• Greenberg Jacquie, Bardien Soraya and Carr Jonathan. (2008) Huntington's disease--like 2 in South Africa. S Afr Med J 98:166.
• Greyling BJ, Kryger P, du Plessis S, van Hooft WF, van Helden P, Getz WM and Bastos ADS . (2008) Development of a high-throughput microsatelite typing approach for forensic and population genetic analysis of wild and domestic African Bovini . African Journal of Biotechnology 7(5):655-660.
• Hanekom M§, van der Spuy G D§, Gey van Pittius N C, McEvoy C R E, Hoek K G P, Ndabambi S L, Jordaan A M, Victor T C, van Helden P D and Warren R M. (2008) Discordance between MIRU-VNTR and IS6110 RFLP genotyping when analyzing Mycobacterium tuberculosis Beijing strains in a high incidence setting. J Clin Microbiol 46(10):3338-45.
• Harper Catriona, Hayward Don, Wiid Ian and van Helden Paul. (2008) Regulation of nitrogen metabolism in Mycobacterium tuberculosis: A comparison with mechanisms in Corynebacterium glutamicum and Streptomyces coelicolor. IUBMB Life 60(10):643-50.
• Hemmings Sîan M J, Kinnear Craig J, Van Der Merwe Lize, Lochner Christine, Corfield Valerie A, Moolman-Smook Johanna C and Stein Dan J. (2008) Investigating the role of the brain-derived neurotrophic factor (BDNF) val66met variant in obsessive-compulsive disorder (OCD). World J Biol Psychiatry 9(2):126-34.
• Hesseling Anneke C, Mandalakas Anna M, Kirchner Lester H, Chegou Novel N, Marais Ben J, Zhu Xiaobei, Black Gillian F, Stanley Kim, Beyers Nulda and Walzl Gerhard. (2008) Highly Discordant T-Cell Responses In Individuals With Recent Household Tuberculosis Exposure. Thorax.
• Hoek K G P, Gey van Pittius N C, Moolman-Smook H, Carelse-Tofa K, Jordaan A, van der Spuy G D, Streicher E, Victor T C, van Helden P D and Warren R M. (2008) Fluorometric assay for testing rifampin susceptibility of Mycobacterium tuberculosis complex. J Clin Microbiol 46:1369-73.
• Johnson R, Jordaan AM, Warren R, Bosman M, Young D, van Helden PD and Victor TC. (2008) Drug susceptibility testing using molecular techniques can enhance TB diagnosis. JIDC 2:40-45.
• Karboul Anis, Mazza Alberto, Gey van Pittius Nicolaas C, Ho John L, Brousseau Roland and Mardassi Helmi. (2008) Frequent homologous recombination events in Mycobacterium tuberculosis PE/PPE multigene families: potential role in antigenic variability. J Bacteriol 190:7838-46.
• Mandalakas A M, Hesseling A C, Chegou N N, Kirchner H L, Zhu X, Marais B J, Black G F, Beyers N and Walzl G. (2008) High level of discordant IGRA results in HIV-infected adults and children. Int J Tuberc Lung Dis 12:417-23.
• Marais Ben J, Brittle Wendy, Painczyk Katrien, Hesseling Anneke C, Beyers Nulda, Wasserman Elizabeth, van Soolingen Dick and Warren Rob M. (2008) Use of light-emitting diode fluorescence microscopy to detect acid-fast bacilli in sputum. Clin Infect Dis 47:203-7.
• McEvoy CRE, Newton-Foot M, van Helden PD and Warren RM. (2008) The Phenotypic effects of insertion sequence-mediated gene activiation in Human Pathogens. In: DNA Transposable Elements Research. pp: 133–155. eds Yoshida K and Aoki M, Nova Publications (New York).
• Mehtar S, Wiid I and Todorov S D. (2008) The antimicrobial activity of copper and copper alloys against nosocomial pathogens and Mycobacterium tuberculosis isolated from healthcare facilities in the Western Cape: an in-vitro study. J Hosp Infect 68:45-51.
• Michel A L, Coetzee M L, Keet D F, Maré L, Warren R, Cooper D, Bengis R G, Kremer K and van Helden P. (2008) Molecular epidemiology of Mycobacterium bovis isolates from free-ranging wildlife in South African game reserves. Vet Microbiol.
• Millen Stephen J, Uys Pieter W, Hargrove John, van Helden Paul D and Williams Brian G. (2008) The effect of diagnostic delays on the drop-out rate and the total delay to diagnosis of tuberculosis. PLoS ONE 3:e1933.
• Mlambo C K, Warren R M, Poswa X, Victor T C, Duse A G and Marais E. (2008) Genotypic diversity of extensively drug-resistant tuberculosis (XDR-TB) in South Africa. Int J Tuberc Lung Dis 12:99-104.
• Moolman-Smook JC, Vermoter CL, Buckle J and Lindenberg L. (2008) Of Rain Men and Snowcakes: The presentation, pathology, aetiology and management of autistic spectrum disorder. SAJCH 2:8-12.
• Parsons S D C, Gous T A, Warren R M and van Helden P D. (2008) Pulmonary Mycobacterium tuberculosis (Beijing strain) infection in a stray dog. J S Afr Vet Assoc 79:95-8.
• Parsons Sven, Smith Sarah G D, Martins Quinton, Horsnell William G C, Gous Tertius A, Streicher Elizabeth M, Warren Robin M, van Helden Paul D and Gey van Pittius Nicolaas C. (2008) Pulmonary infection due to the dassie bacillus (Mycobacterium tuberculosis complex sp.) in a free-living dassie (rock hyrax-Procavia capensis) from South Africa. Tuberculosis (Edinb) 88:80-3.
• Pheiffer C, Carroll N M, Beyers N, Donald P, Duncan K, Uys P and van Helden P. (2008) Time to detection of Mycobacterium tuberculosis in BACTEC systems as a viable alternative to colony counting. Int J Tuberc Lung Dis 12:792-8.
• Rajapaksa U S, Victor T C, Perera A J, Warren R M and Senevirathne S M P. (2008) Molecular diversity of Mycobacterium tuberculosis isolates from patients with pulmonary tuberculosis in Sri Lanka. Trans R Soc Trop Med Hyg 102:997-1002.
• Revera Miriam, van der Merwe Lize, Heradien Marshall, Goosen Althea, Corfield Valerie A, Brink Paul A and Moolman-Smook Johanna C. (2008) Troponin T and beta-myosin mutations have distinct cardiac functional effects in hypertrophic cardiomyopathy patients without hypertrophy. Cardiovasc Res 77:687-94.
• Ronacher Katharina, Hadley Katie, Avenant Chanel, Stubsrud Elisabeth, Simons S Stoney Jr, Louw Ann and Hapgood Janet P. (2008) Ligand-selective transactivation and transrepression via the glucocorticoid receptor: Role of cofactor interaction. Mol Cell Endocrinol.
• Rustomjee R, Lienhardt C, Kanyok T, Davies G R, Levin J, Mthiyane T, Reddy C, Sturm A W, Sirgel F A, Allen J, Coleman D J, Fourie B, Mitchison D A and . (2008) A Phase II study of the sterilising activities of ofloxacin, gatifloxacin and moxifloxacin in pulmonary tuberculosis. Int J Tuberc Lung Dis 12:128-38.
• Schwartz Peter J, Vanoli Emilio, Crotti Lia, Spazzolini Carla, Ferrandi Chiara, Goosen Althea, Hedley Paula, Heradien Marshall, Bacchini Sara, Turco Annalisa, La Rovere Maria Teresa, Bartoli Antonella, George Alfred L Jr and Brink Paul A. (2008) Neural control of heart rate is an arrhythmia risk modifier in long QT syndrome. J Am Coll Cardiol 51:920-9.
• Scriba Thomas J, Kalsdorf Barbara, Abrahams Deborah-Ann, Isaacs Fatima, Hofmeister Jessica, Black Gillian, Hassan Hisham Y, Wilkinson Robert J, Walzl Gerhard, Gelderbloem Sebastian J, Mahomed Hassan, Hussey Gregory D and Hanekom Willem A. (2008) Distinct, specific IL-17- and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response. J Immunol 180:1962-70.
• Sirgel FA, Wiid I and van Helden PD. (2008) Measuring Minimum Inhibitory Concentrations in Mycobacteria. In: Methods in Molecular Biology: Mycobacterium Protocols. pp: 173-186. eds Parish Tanya and Brown Amanda Claire, Humana Press, New York.
• Strauss O J, Warren R M, Jordaan A, Streicher E M, Hanekom M, Falmer A A, Albert H, Trollip A, Hoosain E, van Helden P D and Victor T C. (2008) Spread of a low-fitness drug-resistant Mycobacterium tuberculosis strain in a setting of high human immunodeficiency virus prevalence. J Clin Microbiol 46:1514-6.
• Todorov S D, Botes M, Guigas C, Schillinger U, Wiid I, Wachsman M B, Holzapfel W H and Dicks L M T. (2008) Boza, a natural source of probiotic lactic acid bacteria. J Appl Microbiol 104:465-77.
• van der Spuy G D and Warren R M. (2008) Molecular epidemiology of Mycobacterium tuberculosis. In: Handbook of tuberculosis: clinics, diagnostics, therapy and epidemiology. Vol. 3. pp: 41-62. eds Kaufmann H E and van Helden P D, Wiley-VCH Verlag GmbH & Co, Weinheim.
• van Helden Paul D, Gey van Pittius Nico C, Warren Robin M, Michel Anita, Hlokwe Tiny, Morar Darshana, Godfroid Jacques, du Plessis Elizabeth C and Bengis Roy. (2008) Pulmonary infection due to Mycobacterium goodii in a spotted hyena (Crocuta crocuta) from South Africa. J Wildl Dis 44:151-4.
• van Helden Paul D, Warren Robin M and Uys Pieter. (2008) Predicting reinfection in tuberculosis. J Infect Dis 197:172-3.
• Veenstra Hanne, Baumann Ralf, Lukey Pauline T, Beyers Nulda, van Helden Paul D and Walzl Gerhard. (2008) High levels of intracellular IL-4 are expressed in circulating apoptotic T cells in patients with tuberculosis and in community controls. Tuberculosis (Edinb) 88:21-30.
• Walzl Gerhard, Ronacher Katharina, Djoba Siawaya Joel Fleury and Dockrell Hazel M. (2008) Biomarkers for TB treatment response: challenges and future strategies. J Infect 57:103-9.
• Warren RM, van Helden PD and Gey van Pittius NC. (2008) Insertion element IS6110-based Restriction Fragment Length Polymorphism (RFLP) Genotyping of Mycobacterium tuberculosis. In: Methods in Molecular Biology: Mycobacterium Protocols. Vol. 465. pp: 353-370. eds Parish Tanya and Brown Amanda Claire, Humana Press, New York.
• Ziskind Ari, Bardien Soraya, van der Merwe Lize and Webster Andrew R. (2008) The frequency of the H402 allele of CFH and its involvement with age-related maculopathy in an aged Black African Xhosa population. Ophthalmic Genet 29:117-9.
  

2007

• Abdallah AM, Gey van Pittius NC, Champion PAD, Cox J, Luirink J, Vandenbroucke-Grauls CMJE, Appelmelk BJ and Bitter W. (2007) Type VII Secretion - Mycobacterium shows the way. Nature Reviews Microbiology 5 (11):883-891.
• Albert H Trollip AP Seaman T Abrahams CA Mole RJ Jordaan A Victor T Hoosain E. (2007) Evaluation of a rapid screening test for rifampicin resistance in re-treatment tuberculosis patients in the Eastern Cape. S.A.Med.J. 97:858-863.
• Babb C, Hanekom- Keet E, van Helden PD and Hoal EG. (2007) SP110 polymorphisms are not associated with pulmonary tuberculosis in a South African population. Hum Genet 121 (3-4):521-522.
• Babb C, van der Merwe L, Beyers N, Pheiffer C, Walzl G, Duncan K, van Helden P and Hoal EG. (2007) Vitamin D receptor gene polymorphisms and sputum conversion time in pulmonary tuberculosis patients. Tuberculosis (Edinb) 87 (4):295-302.
• Bardien S, Abrahams F, Soodyall H, van der Merwe L, Greenberg J, Brink T and Carr J. (2007) A South African mixed ancestry family with Huntington disease-like 2: Clinical and genetic features. Mov Disord In print.
• Barreiro LB, Neyrolles O, Babb C, van Helden PD, Giquel B, Hoal E and Quintana-Murci L. (2007) Length Variation of DC-Sign and L-SIGN neck-region has no impact on Tuberculosis Susceptibility. Human Immunolgy 68:106-112.
• Bourn WR Jansen Y Stutz H Warren RM Williamson A van Helden PD. (2007) Creation and characterisation of a high-copy-number version of the pAL 5000 mycobacterial replicon. Tuberculosis 87:481-488.
• Carr JA, van der Walt PE, Nakayama J, Fu YH, Corfield VA, Brink PA and Ptachek L. (2007) FAME 3: A novel form of progressive myoclonis and epilepsy. Neurology 68 (17):1382-1389.
• Chihota V, Apers L, Mungofa S, Kasongo W, Nyoni IM, Tembwe R, Mbulo G, Tembo M, Streicher EM, van der Spuy GD, Victor TC, van Helden P and Warren RM. (2007) Predominance of a single genotype of Mycobacterium tuberculosis in regions of Southern Africa. Int J Tuberc Lung Dis 11(3):311-318.
• Diacon AH, Patientia RF, Venter A, van Helden PD, Smith PJ, McIlleron H, Maritz JS and Donald PR. (2007) The early bactericidal activity of high dose rifampin in patients with sputum smear-positive pulmonary tuberculosis. Antimicrob.Agents Chemother. 51 (8):2994-2996.
• Djoba Siawaya JF, Ruhwald M, Eugen-Olsen J and Walzl G. (2007) Correlates for disease progression and prognosis during concurrent HIV/TB infection. Int J Infect Dis 11 (4):289-299.
• Donald PR, Parkin DP, Seifart HI, Schaaf HS, van Helden PD, Werely CJ, Sirgel FA, Venter A and Maritz JS. (2007) The influence of dose and N-acetyltransferase-2 (NAT2) genotype and phenotype on the pharmacokinetics and pharmacodynamics of isoniazid. Eur J Clin Pharmacol 63 (7):633-639.
• Hanekom M, van der Spuy GD, Streicher E, Ndabambi SL, McEvoy CRE, Kidd M, Beyers N, Victor TC, van Helden PD and Warren RM. (2007) A recently evolved sublineage of the Mycobacterium tuberculosis Beijing strain family was associated with an increased ability to spread and cause disease. J Clin. Microbiol 45 (5):1483-1490.
• Hanekom M, van der Spuy GD, Gey van Pittius NC, McEvoy CR, Ndabambi SL, Victor TC, Hoal EG, van Helden PD and Warren RM. (2007) Evidence that the spread of Mycobacterium tuberculosis strains with the Beijing genotype is human population dependent.. J Clin Microbiol In print.
• Hemmings SMJ, Kinnear CJ, van der Merwe L, Lochner C, Corfield VA, Moolman-Smook JC and Stein DJ. (2007) Investigating the role of the brain-derived neurotrophic factor (BDNF) val66met variant in obsessive-compulsive disorder (OCD). Int.J.Neuropsychopharm. Accepted.
• Heradien M, Goosen A, Moolman-Smook JC and Brink PA. (2007) Race and gender representation of hypertrophic cardiomyopathy or long QT syndrome cases in a South African research setting Cardiovascular Journal of South Africa. Cardiovascular Journal of South Africa Accepted.
• Louw DS, Meyer D, Ziskind A, Werely CJ and and van Helden PD. (2007) An Investigation into the NAT2 acetylator genotype of patients with age-related macular degeneration. Ophthalmic Genetics NOPG 26.
• Maree F, Hesseling AC, Schaaf HS, Marais BJ, BeyersN, van Helden P, Warren RN and Schoeman JF. (2007) Absence of an association between Mycobacterium tuberculosis genotype and clinical features in children with tuberculous meningitis.. Pediatr Infect Dis J. 26 (1):8-13.
• McEvoy CRE Falmer AA Gey van Pittius NC Victor TC van Helden PD Warren RM. (2007) The role of IS6110 in the evolution of Mycobacterium tuberculosis. Tuberculosis.
• Mehtar S, Wiid I and Todorov SD. (2007) The anti microbial activity of copper and copper alloys against nosocomial pathogens and Mycobacterium tuberculosis isolated from healthcare facilities in the Western Cape - an in-vitro study. JHI Accepted.
• Michel AL, de Klerk LM, Gey van Pittius NC, Warren RM and van Helden PD. (2007) Bovine tuberculosis in African buffaloes: Observations regarding Mycobacterium bovis shedding into water and exposure to environmental mycobacteria. BMC Veterinary Research 3:23:1-23.
• Mistry R, Cliff JM, Clayton CL, Beyers N, Mohamed YS, Wilson PA, Dockrell HM, Wallace DM, van Helden PD, Duncan K and Lukey PT. (2007) Gene-Expression Patterns in Whole Blood Identify Subjects at Risk for Recurrent Tuberculosis. Gene Expression in Human Tuberculosis 195 (1):357-365.
• Mitchison DA Jindani A Davies GR Sirgel F. (2007) Isoniazid activity is terminated by bacterial persistance. J Infect Dis 195 (12):1872-2.
• Moller M , Kwiatkowski R, Nebel A, van Helden PD, Hoal EG and Schreiber S. (2007) Allelic variation in BTNL2 and susceptibility to tuberculosis in a South African population. Microbes and Infection 9 (4):522-528.
• Moller M, Nebel A, Kwiatkowski R, van Helden PD, Hoal EG and Schreiber S. (2007) Host suceptibility to tuberculosis: CARD 15 polymorphisms in a South African population. Mol Cell Probes 21(2):148-151.
• Parsons S, Smith SGD, Martins Q, Horsnell WGC, Gous TA, Streicher EM, Warren RM, van Helden PD and Gey van Pittius NC. (2007) Pulmonary infection due to the dassie bacillus (Mycobacterium tuberculosis complex sp) in a free-living dassie (rock hyrax-Procavia capensis) from South Africa. Tuberculosis Accepted.
• Revera M, , van der Merwe L, Heradien M, Goosen A, Corfield VA, Brink PA and Moolman-Smook JC. (2007) Long-term follow-up of R403W(MYH7) and R92W(TNNT2) HCM families: mutations determine left ventricular dimensions, but not wall thickness, during disease-progression. Cardiovasc J S Afr 18 (3):146-153.
• Roberts T, Beyers N, Aguirre A and Walzl G. (2007) Immunosuppression during Active Tuberculosis is characterized by Decreased Interferon - Gamma Production and CD25 Expression with Elevated Forkhead Box P3, Transforming Growth Factor - and Interleukin-4 mRNA Levels. Journal of Infectious Diseases 195:870-878.
• Schaaf HS, Victor TC, Engelke E, Brittle W, Marais BJ, Hesseling AC, van Helden PD and Donald PR. (2007) Minimal inhibitory concentration of isoniazid in isoniazid in isoniazid-resistant Mycobacterium tuberculosis isolates from children. Eur J Clin Microbiol Infect.Dis. 26 (3):203-205.
• Schwartz P J, Vanoli E, Crott L, Spazzolini C, Ferrandi C, Goosen A, Hedley P, Heradien M, Bacchini S, Turco A, La Rovere MT, Bartoli A, George AL Jr and Brink PA. (2007) Neural Control of Heart Rate is an Arrhythmia Risk Modifier in Long QT Syndrome. A contributory role for common genetic variants. Circulation In Press.
• Streicher EM, Victor TC, van der Spuy G, Sola C, Rastogi N, van Helden PD and Warren RM. (2007) Spoligotype signatures in the Mycobacterium tuberculosis complex. J.Clin.Microbiol. 45 (1):237-240.
• Todorov SD, Botes M, Guigas C, Schillinger U, Wiid I, Wachsman MB, Holzapfel WH and Dicks LM. (2007) Boza, a natural source of probiotic lactic acid bacteria. J Appl Microbiol. In print.
• Uys PW Warren RM van Helden PD. (2007) A threshold value for the time delay to TB diagnosis. PLoS Medicine One 8 e757:1-6.
• van Helden PD, Warren RM and Uys P. (2007) Predicting reinfection in TB. Journal of Infectious Diseases Accepted.
• Veenstra H, Baumann R, Lukey P, Beyers N, van Helden PD and Walzl G. (2007) High levels of intracellular IL-4 are expressed in circulating apoptotic T cells in patients with tuberculosis and community controls. Tuberculosis Accepted.
• Victor TC, Streicher EM Kewley C, Jordaan AM van der Spuy GD, Bosman M, Louw H, Murray M, Young D, van Helden PD and Warren RM. (2007) Spread of an emerging Mycobacterium tuberculosis drug resistant strain in the Western Cape of South Africa. Int J Tub Lung Dis 11(2):195-201.
• Werely CJ, Donald PR and van Helden PD. (2007) Nat2 polymorphisms and their influence on the pharmacology and toxicity of isoniazid in TB patients. Personalized Medicine 4(2).

2006

• Adams VJ, Markus MB, Kwitshana ZL, Dhansay MA, van der Merwe L, Walzl G and Fincham JE. (2006) Recall of intestinal helminthiasis by HIV-infected South Africans and avoidance of possible misinterpretation of egg excretion in worm/HIV co-infection analyses.. BMC Infect Dis. 26:6-88.
• Bardien S Abrahams F Soodyall H van der Merwe L Greenberg J Brink J Brink T Carr J. (2006) Arrhythmogenic right ventricular cardiomyopathy type 6 (ARVC6):support for the locus assignment, narrowing of the critical region and mutation screening of three candidate genes. BMC Med Genet 28:7-29.
• Barreiro LB, Neyrolles O, Babb CL, Tailleux L, Quach H, McElreavey K, van Helden PD, Hoal EG and Gicquel Bquintana-Murci L. (2006) Promoter Variation in the DC-SIGN-Encoding Gene CD209 is associated with Tuberculosis. PLoS Medicine 3:1-6.
• Brahmbhatt S Black G F Nora M Carroll N M Beyers N Salker F Kidd M Lukey PT Duncan K van Helden P Walzl G. (2006) Immune markers measured before treatment predict outcome of intensive phase tuberculosis therapy. Clinical & Experimental Immunology.
• Brudey K van Helden PD Victor TC Warren RM and 61 others. (2006) Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology.. BMC Microbiology 6:6-23.
• Chauke G Bardien S Moolman-Smook H Freeman V Makubalo Z Brink P Corfield V. (2006) Novel mutations idenfified within the 3' region of the PKDI gene in South African polycystic kidney disease patients. S.A.J.Science In Press.
• Culley FJ, Pennycook AM, Tregoning JS, Dodd JS, Walzl G, Wells TN, Hussell T and Openshaw PJ. (2006) Role of CCL5 (RANTES) in Virul Lung Disease. Viral Lung Disease 80 (16):8151-8157.
• Gey van Pittius, Sampson SL, Lee H, Kim Y, van Helden PD and Warren RM. (2006) Evolution and expansion of the Mycobaterium tuberculosis PE and PPE Multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions. BMC Evolutionary Biology.
• Glynn J, plus (71) authors including van Helden PD, Warren RM and Richardson M. (2006) Worldwide distribution of Beijing/W genotype Mycobacterium tuberculosis and associations with drug resistance: a collaborative study in 35 countries. Emerging Infectious Disease (Accepted).
• Hemmings SM Kinnear CJ Lochner C Seedat S Corfield VA Moolman-Smook JC Stein DJ. (2006) Genetic correlates in trichotillomania - A case-control association study in the South African Caucasian population. Israel Journal of Psychiatry (In Press) 43 (2):93-101.
• Hemmings SMJ and 2006 Stein DJ. (2006) The Current Status of Association Studies in Obsessive- Compulsive Disorder. Psychiatric Clinics of North America 2:411--44.
• Hemmings SMJ, Kinnear CJ, Lochener C, Seedat S, Corfield VA, Moolman-Smook H and Stein DJ. (2006) Genetic correlates in Trichotillomania: a case-control association study in the South African Caucasian population. Israel Journal of Psychiatry (In Press).
• Hemmings SMJ and Stein DJ. (2006) Studies in Obsessive-Compulsive Disorder. Psychatric Clinics of North America. Psychiatric Clinics of North America 2:411-444.
• Heradien Marshall J, Goosen Althea, Crotti Lia, Durrheim Glenda, Corfield Valerie and Brink Paul A. (2006) Does pregnancy increase cardiac risk for LQT1 patients with the KCNQ1-A341V mutation. J.Am.College of Cardiologists In Press.
• Hesseling AC, Rabie H, Marais BJ, Manders M, Lips M, Schaaf HS, Gie RP, Cotton MF, van Helden PD, Warren RM and Beyers N. (2006) Bacille Calmette-Guerin Vaccine induces disease in HIV infected and HIV uninfected Children.. Clinical Infectious Diseases 42:548-558.
• Hillerman D, Warren RM, Kubica T, Rusch-Gerdes S and Niemann S. (2006) The Beijing genotype and drug resistant tuberculosis in the Aral Sea region of Central Asia. Strains by Real-Time PCR.. J Clin Microbiol 44 (2):302-306.
• Hillerman D, Warren R, Kubica, Rusch-Gerdes S and Niemann S. (2006) Rapid detection of Mycobacterium tuberculosis Beijing genotype strains by real-time PCR.. J Clin Microbiol. 44(2):302-306.
• Hofman-Bang J, Behr ER, Hedley P, Tfelt-Hansen J, Kanters JK, Haunsoe S, McKenna WJ and Christiansen M. (2006) High-efficiency multiplex capillary electrophoresis single strand conformation polymorphism (multi-CE-SSCP) mutation screening of SCN5A: a rapid genetic approach to cardiac arrhythmia.. Clin Genet. 69:504-511.
• Hofman-Bang J, Behr ER, Hedley P, Tfelt-Hansen J, Kanters JK, Haunsoe S, McKenna WJ and Christiansen M. (2006) High-efficiency multiplex capillary electrophoresis single strand conformation polymorphism (multi-CE-SSCP) mutation screening of SCN5A: a rapid genetic approach to cardiac arrhythmia.. Clin Genet. 69(6):504-511.
• Johnson R Streicher EM Louw GE Warren RM van Helden PD Victor TC. (2006) Drug Resistance in Mycobacterium tuberculosis. Curr.Issues Mol. Biol. 8:97-112.
• Johnson R, Jordaan AM, Pretorius L, Engelke E, Van der Spuy GD, Kewley C, Bosman M, van Helden PD and Warren RM. (2006) Ethambutol resistant testing by mutation detection. Int J Tub Lung Dis 10 (1):68-73.
• Johnson R, Streicher EM, Louw GE, Warren RM, van Helden PD and Victor TC. (2006) Drug Resistance in Mycobacterium tuberculosis. Mol.Biol.Reports 8:97-112.
• Johnson R, Warren RM, Strauss O, Jordaan A: Falmer A, Beyers N, Schaaf S, Cloete K, Murray M, van Helden P and Victor T. (2006) An outbreak of drug resistant tuberculosis cause by a Beijing strain in the Western Cape. IJTLD (accepted).
• Lochner C Hemmings S Seedat S Kinnear C Schoeman R Annerbrink K Olsson M Eriksson E Moolman-Smook H Allgulander C Stein DJ. (2006) Genetics and personality traits in patients with social anxiety disorder: A case-control study in South Africa. Eur Neuropsychopharmacol In Print.
• Lombard Z, Bruce AE, Hoal EG, Babb C, Van Helden PD, Epplen JT and Bornman L. (2006) HLA Class II disease associations in Southern Africa. Tissue Antigens.. Tissue Antigens 67 (2):97-110.
• Louw GE, Warren RM, Donald PR, Murray MB, Bosman M, van Helden PD, Young DB and Victor TC. (2006) Frequency and implications of Pyrazinamide resistance in managing previously treated tuberculosis patients. Pyrazinamide resistance in tuberculosis. Int J Tub Lung Dis 10 (7):802-807.
• Moolman-Smook JC and Brink PA. (2006) Searching for the holy grail of cardiac functional assessment: the role for tissue Doppler, strain and strain rate imaging. Cardiovasc.J.S.A. In press.
• Möller M Nebel A Kwiatkowski R van Helden PD Hoal EG Schreiber S. (2006) Host susceptibility to tuberculosis: CARD15 polymorphisms in a South African population. Mol Cell Probes Accepted.
• Sirgel FA, Maritz JS, Venter A, Langdon G, Smith PJ and Donald PR. (2006) Monitoring the ingestion of anti-tuberculosis drugs by simple non-invasive methods. Int J Pharmaceuticals 307:182-187.
• Smith J, Hoal van Helden EG, Coetzee AR, van Helden PD Maritz JS, Pieper CH, James R and Janse van Rensburg J. (2006) Addition of trehalose to dipalmitoyl phosphatidylcholine, hexadecanaol and tyloxapol improves oxygenation in surfactant-deficient rabbits. South African Journal of Science 102.
• Stein DJ DanielsW Emsley R Harvey B Blackburn J Carey P Ellis G Illing N Flisher A Moolman-Smook H Mwaba K Ramesar R Russel V Seedat S Tredoux C Vaughan CL Vythilingum B Warwick J. (2006) A brain-behaviour initiative for South Africa : the time is right. Metab Brain Dis. In Print.
• van Helden P, Victor T, Walzl G, Warren R, Hoal E, Donald P and Schaaf H. (2006) Antimicrobial resistance in tuberculosis : an international perspective. Expert review of anti-infective therapy. Accepted.
• van Helden PD Victor T Warren RM. (2006) The "Source" of Drug-Resistant TB Outbreaks. Science 314:419-420.
• Veenstra R, Baumann NM, Carroll PT, Lukey M, Kidd N, Beyers C T, Bolliger, van Helden P D and Walzl G. (2006) Changes in leukocyte and lymphocyte subsets during tuberculosis treatment; prominence of CD3dim CD56+ Natural Killer T cells in fast treatment responders. Clinical & Experimental Immunology In press.
• Warren R, de Kock M, Engelke E, Myburgh R, Gey van Pittius N, Victor TC and van Helden PD. (2006) Safe Mycobacterium tuberculosis DNA extraction method that does not comprise integrity. J Clin Microbiol 44.1:254-256.
• Warren RM, Gey van Pittius NC, Barnard M, Hesseling A, Engelke E, de Kock M, Gutierrez MC, Chege GK, Hoal EG and van Helden PD. (2006) Differentiation of Mycobacterium complex members by mutiple-PCR amplification of genomic regions of difference. Int J Tub Lung Dis (In Press) 10:818-822.

2005

• Adams VJ, Markus MB, Adams JFA, Jordaan E, Curtis B, Dhansay MA, Obihara CCO and Fincham JE. (2005) Paradoxical helminthiasis and giardiasis in Cape Town, South Africa: epidemiology and control. African Health Science 5(2):131-136.
• Albert H, Trollip PP, Seaman T, Abrahams C, Mole RJ, Victor T and Hoosain E. (2005) Rpid screening for rifampicin resistance in previously treated tuberculosis.. J Clin Microbiol.
• Brahmbhatt S, Black GF, Carroll NM, Salker F, Kidd M, Beyers N, Lukey PT, Kuncan K, van Helden P and Walzl G. (2005) Host immune markers measured before or during intensive phase treatment can predict rate of response to antituberculosis therapy.. Am J Respir Crit Care Med.
• Brink PA, Crotti L, Corfield V, Goosen A, Durheim G, Hedley P, Heradien M, Geldenhuys G, Vanoli E, Bacchini S, Spazzolini C, Lundquist AL, Roden DM, George ALJr and Schwartz PJ. (2005) Phenotypic Variability and Unusual Clinical Severity of Congenital Long QT Syndrome in a Founder Population.
• Fernandez PW, Moolman-Smook JC, Brink PA and Corfield VA. (2005) A gene locus for progressive familial heart block type II (PFHBII) maps to chromosome 1q32.2-132.3. Hum Genet Aug 6:1-5.
• Gey van Pittius NC, Sampson SL, Warren RM, van Helden PD and . (2005) Genome variation in Mycobacterium tuberculosis: pathogen genomics. S.A.J.Science 100:465-470.
• Hillermann D, Warren R, Kubica T, Rusch-Gerdes S and Niemann S. (2005) Detection of Mycobacterium tuberculosis Beijing genotype strains by Real Time PCR.
• Hoal E and van Helden PD. (2005) Genomics fights TB - Stopping the spread of TB. Quest 1(4):3-7.
• Johnson R, Jordaan Am, Pretorius L, Engelke E, van der Spuy G, Kewley C, Bosman M, van Helden PD, Warren R and Victor TC. (2005) Ethambuton Resistance Testing By Mutation Detection.. Int Journal of Tuberculosis and Lung Disease.
• Lochner C, Hemmings SMJ, Kinnear CJNiehaus DJH, Nel DG, Corfield VA, Moolman-Smook JC, Seedat S and Stein DJ. (2005) Cluster analysis of absessive compulsive spectrum disorders in patients with obsessive compulsive disorder: clinical and genetic correlates.. Comprehensive Psychiatry 46:14-19.
• Loots, DT, Wiid, IJ, Page, BJ, Mienie, LJ, van Helden and PD. (2005) Melatonin prevents the free radical and MADD metabolic profiles induced by antituberculosis drugs in an animal model.. J Pineal Res 38:100-106.
• Marais BJ, Obihara CC, Warren RM, Schaaf HS, Gie RP and Donald PR. (2005) The burden of childhood tuberculosis - a public health perspective. Int J Tub Lung Dis.
• Mardassi H, Namouchi N, Haltiti R, Zarrouk M, Mhenni B, Karboul A, Khabouchi N, Gey van Pittius NC, Streicher EM, Rauzier J, Gicquel B and Dellagi K. (2005) Tuberculosis due to Resistant Haarlem Strain, Tunisia.. Emerging Infectious Disease 11(6):957-961.
• Mostowy S, Inwald J, Gordon S, Martin C, WarrenRM, Kremer K, Cousins D and Behr M. (2005) Genomic differences resolve the evolution of Mycobacterium bovis.
• Pheiffer C, Betts JC, Flynn HR, Lukey PT, van Helden PD and . (2005) Protein expression by a Beijing strain differs from that of another clinical isolate and Mycobacterium tuberculosis H37Rv.. Mol.Microbiol. 151:1139-1150.
• Schaaf HS, Hesseling AC, Krook S, Warren RM and Donald PR. (2005) Recurrent confirmed tuberculosis in HIV-infected children.. Pediatr Infect Dis J.
• Schaaf HS, Parkin DP, Seifart HI, Werely CJ, Hesseling PB, van Helden PD, Maritz JS and Donald PR. (2005) Isoniazid pharmacokinetics in children tested for respiratory tuberculosis. Arch. Dis. Child 90:614-618.
• Stopforth A, Tredoux A, Crouch A, van Helden P and Sandra P. (2005) A rapid method of diagnosing pulmonary tuberculosis using stir bar sorptive extraction-thermal desorption-gas chromatography-mass spectrometry.. J Chromatogr A 1071:135-139.
• van Rie A, Victor TC, Richardson M, Johnson R, van der Spuy GD, Murray EJ, Beyers N, Gey van Pittius NC, van Helden PD and Warren RM. (2005) Reinfection and Mixed Infection Cause Changing Mycobacterium tuberculosis Drug-resistance Patterns. Am J Respir Crit Care Med.
• Verver S, Warren RM, Beyers N, Richardson M, van der Spuy GD, Borgdorff MW, Enarson DA, Behr MA and van Helden PD. (2005) Rate of reinfection tuberculosis after successful treatment is higher than rate of new tuberculosis. Am J Respir Crit Care Med 171(12):1430-1435.
• Walzl G, Beyers N and van Helden P. (2005) TB: a partnership for the benefit of research and community. Trans Royal Soc of Tropical Medicine and Hygiene.

2001

• Hoal-van Helden, E.G., Hon, D., Lewis, L.-A., Beyers, N., van Helden, P.D. (2001) Mycobacterial growth in human macrophages: Variation according to donor, inoculum and bacterial strain. Cell Biol. Int. 25, 77-81.
• Hoal-van Helden, E.G., Stanton, L.-A., van Helden, P.D. (2001) Diversity of in vitro cytokine responses by human macrophages to infection by Mycobacterium tuberculosis strains. Cell Biol. Int. 25, 83-90.
• Van Rie, A., Warren, R., Mshanga, I., Jordaan, A.M., van der Spuy, G.D., Richardson, M., Simpson, J., Gie, R.P., Enarson, D.A., Beyers, N., van Helden, P.D., Victor, T.C. (2001) Analysis for a limited number of gene codons can predict drug resistance of Mycobacterium tuberculosis in a high incidence community. JCM 39, 636-641.
• Durrheim, G.A., Garnett, D., Dennehy, K.M., Beyers, A.D. (2001) Thy-1 associated PP85-90 is a potential docking site for SH2 domain-containing signal transduction molecules. Cell Biol. Int. 25 (1), 33-42.
• Dennehy, K.M., Ferris, W.F., Veenstra, H., Zuckerman, L.A., Killeen, N., Beyers, A.D. (2001) Determination of the tyrosine phosphorylation sites in the T cell transmembrane glycoprotein CD5. International Immunology 13 (2), 149-156.
• Corfield, V. (2001) Bringing the human genome home to Africa. Science in Africa.
• Corfield, V. (2001) Personal safaris into the genome. Science in Africa.
• Du Plessis, D.G., Warren, R., Richardson, M., Joubert, J.J., van Helden, P.D. (2001) Demonstration of reinfection and reactivation in HIV-negative autopsied cases of secondary tuberculosis: multilesional genotyping of Mycobacterium tuberculosis utilizing IS6110 and other repetitive element-based DNA fingerprinting. Tuberculosis 81(3): 211-220.
• Veenstra, H., Ferris, W.F., Bouic, P.J.D. (2001) Major histocompatibility complex class II invariant chain expression in non-antigen-presenting cells. Immunology 103, 1-13.
• Van Helden, S.N., Hoal-van Helden, E.G., van Helden, P.D. (2001) Factors influencing Peak Expiratory Flow (PEF) in Teenage Boys. SAMJ (accepted).
• McCluggage, W.G., Maxwell, P., Veenstra, H., Fick, C.E., Laeng, R.H., Tiltman, A.J. (2001) Monoclonal antibody SM047 as an immunohistochemical marker of ovarian adenocarcinoma. Histopathology (accepted).
• Kinnear C., Niehaus D. J., Seedat S., Corfield V. A., Moolman-Smook J. C., Malherbe G., Potgieter A., Lombard C. and Stein D (2001) Obsessive-compulsive disorder and a novel polymorphism adjacent to the estrogen response element (ERE6) upstream from the COMT gene. J. Psych. Genetics (in press).
• Schwartz P.J., Priori S.G., SpazzoliniC., Moss A.J., Vincent G.M., Napolitano C., Denjoy I., Guicheney P., Breithardt G., Keating M.T., Towbin J.A., Beggs A.H., Brink P., Wilde A.A.M., Toivonen L., Zareba W., Robinson J.L., Timothy K.W., Corfield V., Wattanasirichaigoon D., Corbett C., Haverkamp W., Schulze-Bahr E., Lehmann M.H., Schwartz K., Coumel P. and Bloise R. (2001) Genotype-Phenotype Correlation in the Long-QT Syndrome Gene-Specific Triggers for Life-Threatening Arrhythmias. Circulation. 103: 89-95
• Niehaus D. J., Stein D. J and Moolman-Smook J. C. (2001) Is this condition inherited? Lundbeck Inst. Journal (in press).
• Andersen P.S., Havndrup O., Bundgaard H., Moolman-Smook J.C., Larsen L.A., Mogensen J., Brink P.A., Borglum A.D., Corfield V.A., Kjeldsen K., Vuust J. and Christiansen M. Myosin light chain mutations in familial hypertrophic cardiomyopathy: Phenotypic presentation and frequency in Danish and South African populations. Journal of Medical Genetics 2001 (accepted).
• Sampson S., Warren R., Richardson M., van der Spuy G., van Helden P. IS6110 insertions in M.tuberculosis: predominantly into coding regions. Journal of Clinical Microbiology 2001 (letter).
• Warren RM, Richardson M. Sampson SL, van der Spuy GD, Bourn W, Hauman JH, Heersma H, Hide W, Beyers N, van Helden PD. (2001) Molecular evolution of Mycobacterium tuberculosis: Phylogenetic reconstruction of clonal expansion. Tubercle and Lung Disease. (accepted).

2000

• Fenhalls G, Wong A, Bezuidenhout J, van Helden P, Bardin P, Lukey PT. In situ production of IL4 and TNF- mRNA in human lung tuberculous granulomas. Infection and Immunity 68: 2827-2836.
• Bischoff A, Hara T, Lin CH, Beyers AD, Hunig T. Autonomous induction of T-cell proliferation and JNK activation by mobilized CD28. Eur. J. Immunol. 30: 876-882.
• Schaaf H, van Rie A, Gie RP, Beyers N, Victor TC, van Helden PD, Donald PR. Transmission of multidrug resistant tuberculosis. Ped. Infect. Dis. J. 19, 695-699.
• Van Rie A, Warren R, Richardson M, Gie RP, Enarson DA, Beyers N, van Helden PD. Classification of drug-resistant tuberculosis in an epidemic area. Lancet 356: 22-25.
• Brown GD, Dave JA, Gey van Pittius NC, Stevens L, Ehlers MRW, Beyers AD. The mycosins of M.tuberculosis H37Rv: A family of subtilisin-like serine proteases. Gene 254, 147-155.
• Bellamy R, Beyers N, McAdam KPWJ, Ruwende C, Gie R, Samaai P, Bester D, Meyer M, Dorrah T, Collin M, Camidge DR, Wilklinson D, Hoal-van Helden E, Whittle HC, Amos W, van Helden PD, Hill AVS. Genetic susceptibility of tuberculosis in Africans: a genome-wide scan. Proc. Natl. Acad. Sci. (USA) 97: 8005-8009.
• Moolman-Smook JC, de Lange WJ, Corfield VA, Brinl PA. Expression of HCM-causing mutations: lessons learnt from genotype:phenotype studies of the S.A. founder MYH7 A797T mutation. J. Med. Genet. 37: 951-955.
• Niehaus DH, Weyers J, du Toit P, van Kradenburg J, Kinnear CJ, Moolman-Smook JC, Seedat S, Corfield VA, Brink PA, Emsley RA, Knowles JA, Stein DJ. Association between catechol-o-methyltransferase polymorphisms and obsessive- compulsive disorder in the Afrikaner population. J. Aff. Dis. (in press).
• Warren RM, Sampson SL, Richardson M, van der Spuy GD, Lombard CJ, Victor TC, van Helden PD. Mapping of IS6110 flanking regions in clinical isolates of M.tuberculosis demonstrates genome plasticity. Mol. Microbiol. 37(6): 1405-1416.
• Moolman-Smook JC, de Lange WJ, Brink PA, Corfield VA. Hypertrophic cardiomyopathy - repealing tenets in South Africa. Cardiovasc. J. S.A. 11, 202-209.
• Kinnear CJ, Niehaus DJH, Corfield VA, Brink PA et al. Obsessive-compulsive disorder and the promotoer region polymorphism (5-HTTLPR) in the serotonin transporter gene (SLC6A4): a negative association study in the Afrikaner population. Int. J. Neuropsychopharm. (in press).
• Ramljak D, Calvert RJ, Wiesenfeld PW, Diwan BA, Catipovic B, Marasas WF, Victor TC, Anderson LM, Gelderblom WC. A potential mechanism for fumonisin B(1)-mediated hepatocarcinogenesis: cyclin D1 stabilization associated with activation of Akt and inhibition of GSK-3beta activity. Carcinogenesis 21, 1537-1546.

1999

• Van Helden EG, Epstein J, Victor TC, Hon D, Lewis L-A, Beyers N, Zurakowski D, Ezekowitz RAB, van Helden PD. Mannose-binding protein B allele confers protection against tuberculous meningitis. Pediatr. Res. 45: 1-6.
• Adams JFA, Scholvink EH, Gie RP, Potter PC, Beyers N, Beyers AD. Decline in total serum IgE after treatment for tuberculosis. The Lancet 353: 2030-2033.
• Vos M, Warren RM, van Rensburg CJ, Hauman JHH, Epplen JT, van Helden PD. Rapid genomic diversification of Helicobacter pylori. Electrophoresis 20: 1476-1485.
• Wiid I, Hoal-van Helden E, Hon D, van Helden P. Potentiation of isoniazid activity 1against Mycobacterium tuberculosis by melatonin. Antimicrob. Agents Chemotherap. 43: 975-977.
• Classen CN, Warren R, Richardson M, Hauman JH, Gie RP, Ellis JHP, van Helden PD, Beyers N. Impact of social interactions in the community on the transmission of tuberculosis in a high incidence area. Thorax 54: 136-140.
• Warren R, Richardson M, van der Spuy G, Victor T, Sampson S, Beyers N, van Helden P. DNA fingerprinting and molecular epidemiology of tuberculosis: use and interpretation in an epidemic setting. Electrophoresis 20: 1807-1812.
• Du Plessis L, Dietzch E, van Gele M, van Roy N, van Helden P, Park MI, Mugwanya DK, de Groot M, Marx MP, Kotze MJ, Speleman F. Mapping of novel regions of DNA gain and loss by comparative genomic hybridization in esophageal carcinoma in the Black and Colored populations of South Africa. Cancer Res. 59: 1877-1883.
• Sampson SL, Warren RM, Richardson M, van der Spuy GD, van Helden PD. Disruption of coding regions of IS6110 insertion in Mycobacterium tuberculosis. Tubercle & Lung Disease 79: 349-359.
• Redwood CS*, Moolman-Smook JC*, Watkins HC. Properties of mutant contractile proteins that cause hypertrophic cardiomyopathy. Cardiovascular Journal 44: 20-36. [*Joint first authors]
• Victor TC, Jordaan AM, van Rie A, van der Spuy GD, Richardson M, van Helden PD, Warren R. Detection of mutations in drug resistance genes of Mycobacterium tuberculosis by a dot-blot hybridization strategy. Tubercle and Lung Disease 79: 343-348.
• Van Rie A, Warren RM, Beyers N, Gie RP, Classen CN, Richardson M, Sampson SL, Victor TC, van Helden PD. Transmission of a multidrug-resistant Mycobacterium tuberculosis strain resembling "strain W" among non-institutional, HIV seronegative patients. Journal of Infectious Diseases 180: 1608-1615.
• Van Helden P, Hoal-van Helden E. Mannose-binding lectin and meningococcal disease. The Lancet 354: 337.
• Van Rie A, Warren RM, Richardson M, Victor TC, Robert GP, Enarson DA, Beyers N, van Helden PD. Exogenous reinfection is a common cause of tuberculosis recurrence after cure. New Eng. J. Medicine 341: 1174-1179.
• Moolman-Smook JC, De Lange WJ, Bruwer ECD, Brink PA, Corfield VA. The origins of hypertrophic cardiomyopathy-causing mutations in two South African sub-populations: a unique profile of both independent and founder events. The American J. Human Genetics 65: 1238-1241.
• Bentwich Z, Kalinkovich A, Weisman Z, Borkow G, Beyers N, Beyers AD. Can eradication of helminthic infections change the face of AIDS and tuberculosis? Immunol. Today 20: 485-487.
• Pena-Rosse C, Zucker LA, Strong J, Kwan J, Ferris W, Tarakhovsky A, Beyers AD, Killeen N. Negative regulation of CD4 lineage development and responses by CD5. J. Immunology 163: 6494-6501.
• Beyers AD. Regulation of intracellular signalling by protein prenylation. S. A. Med. J 89: 430. (Editorial).