HIV Prevention Research Unit
HPTN
035: Phase II/IIb Safety and Effectiveness Study of the Vaginal Microbicides
BufferGel and 0.5% PRO 2000/5 Gel (P) for the Prevention of HIV Infection
in Women
Principle Investigator: Dr Gita Ramjee
Project Leader: Dr Roshini Govinden
Primary Objectives:
 |
To evaluate the safety
of BufferGel and 0.5% PRO 2000/5 Gel (P) when applied intravaginally by
women at risk for sexually-transmitted HIV infection. |
|
To estimate the effectiveness
of BufferGel and 0.5% PRO 2000/5 Gel (P) in preventing HIV infection among
at-risk women. |
Secondary Objectives:
|
To estimate the effectiveness
of BufferGel and 0.5% PRO 2000/5 Gel (P) in preventing the following among
women at risk for sexually-transmitted HIV infection: |
Processing of samples, Hlabisa
- bacterial
vaginosis
- chlamydia infection
- genital ulcer disease
- gonorrhea infection
- herpes simplex virus-2
infection
- pregnancy
- syphilis infection
- trichomoniasis
|
