Receptor Biology Research Unit

Publications

(2000-2001)

1. Millar, R.M., Lowe, S., Conklin, D., Pawson, A., Maudsley, S., Troskie, B., Ott, T., Millar, M., Lincoln, G., Sellar, R. Faurholm, B., Scobie, G., Kuestner, R., Terasawa, E. and Katz, A. (2001). A novel receptor for the evolutionarily conserved Type II gonadotropin-releasing hormone. Proc. Nat. Acad. Sci. In press
2. Parhar, I.S., Soga, T., Sakuma, Y. and Millar, R.P. (2001). Spatio-temporal expression of GnRH receptor subtypes in gonadotropes, somatotropes and lactotropes in the cichlid fish. General and Comparative Endocrinology. In press
3. Kitanovic, S., Yuen, T., Flanagan, C. A., Ebersole, B. J. and Sealfon, S, C. (2001) Insertional Mutagenesis of the Arginine Cage Domain of the Gonadotropin-Releasing Hormone Receptor, Mol Endocrinol 15: 390-397.
4. Hislop, J.N., Madziva, M.T., Everest, H.M., Harding, T., Uney, J.B., Willars, G.B., Millar, R.P., Troskie, B.E., Davidson, J.S. and McArdle, C.A. (2001). Desensitization and internalization of human and Xenopus gonadotropin-releasing hormone receptors expressed in alpha T4 pituitary cells using recombinant adenovirus. Endocrinology 141, 4564-4575
5. Sales, K.J., Katz, A.A., Davis, M., Hinz, S., Soeters, R.P., Hofmeyr, M.D., Millar, R.P. and Jabbour, H.N. (2001) Cyclooxygenase-2 expression and prostaglandin E2 synthesis are up-regulated in carcinomas of the cervix: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors. Journal of Clinical Endocrinology and Metabolism 86, 2243-2249
6. Robinson, R.R., White, R.B., Illing, N., Troskie, B.E., Morley, M., Millar, R.P. and Fernald, R.D. (2001). Gonadotropin-releasing hormone receptor in the teleost Haplochromis burtoni: structure, location and function. Endocrinology 142, 1737-1743
7. Wang, L., Bogerd, J., Choi, H.S., Soh, J.M., Chun, S.Y., Blomenröhr, M., Troskie, B.E., Millar, R.P. and Kwon, H.B. (2001) Three distinct types of gonadotropin-releasing hormone receptor characterized in a single diploid species. Proc. Nat. Acad. Sci. 98, 3610366
8. Sun, Y.M., Flanagan, C.A., Illing, N., Ott, T.R., Sellar, R., Fromme, B.J., Hapgood, J., Sharp, P., Sealfon, S.C. and Millar, R.P. (2001). A chicken gonadotropin-releasing hormone receptor that confers agonist activity to mammalian antagonists: identification of D-Lys6 in the ligand and extracellular loop two of the receptor as determinants. Journal of Biological Chemistry 276, 7754-7761
9. Sun, Y-M., Dunn, I.C., Baines, E., Talbot, R.T., Illing, N., Millar, R.P. and Sharp, P.J. (2001) Distribution and regulation by oestrogen of fully processed and variant transcripts of gonadotropin-releasing hormone I and gonadotropin-releasing hormone receptor mRNAs in the male chicken J Neuroendocrinol 13, 37-49
10. Flanagan, C.A., Rodic, V., Konvicka, K., Yuen, T., Chi, L., Rivier, J.E., Millar, R.P., Weinstein, H. and Sealfon, S.C. (2000) Multiple interactions of the Asp2.61(98) side chain of the gonadotropin-releasing hormone receptor contribute differentially to ligand interaction. Biochemistry 39, 8133-8141
11. Soule, S.G., Macfarlane, P., Levitt, N.S. and Millar, R.P. (2001) Contributions of growth hormone-releasing hormone and somatostatin to decreased growth hormone secretion of elderly men. South African Medical Journal 91, 254-260
12. King, JA, Fidler, A., Lawrence, S., Adam, T., Millar, R.P. and Katz, A. (2000). Cloning and expression, pharmacological characterization, and internalisation kinetics of the pituitary GnRH receptor in a metatherian species of mammal Gen Comp Endocrinol 117, 439-448
13. Conklin, D.C., Rixon, M.W., Kuestner, R.E., Maurer, M.F., Whitmore, T.E. and Millar, R.P. (2000). Cloning and gene expression of a novel human ribonucleoprotein. Biochemica and Biophysica Acta 1492, 465-469
14. Yoo, M.S. Kang, H.M., Choi, H.S., Kim, J.W., Troskie, B.E., Millar, R.P. and Kwon, H.B. (2000). Molecular cloning, distribution and pharmacological characterization of a novel gonadotropin-releasing hormone ([Trp8] GnRH) in frog brain. Molecular and Cellular Endocrinology 164, 197-204
15. Troskie, B.E., Hapgood, J.P., Millar, R.P. and Illing, N. (2000) cDNA cloning, gene expression and ligand selectivity of a novel GnRH receptor expressed in the pituitary and midbrain of Xenopus laevis. Endocrinology 141, 1764-1771
16. Conklin, D., Yee, D.P., Millar, R., Engelbrecht, J. and Vissing, H. (2000). Mining of assembled expressed sequence tag (EST) data for protein families: application to the G-protein coupled receptor superfamily Briefings in Bioinformatics 1, 93-99

Submitted Papers

1. Fromme, B. J., Katz, A. A., Roeske, R. W., Millar, R. P., Flanagan, C. A. Role of aspartate7.32(302) of the human gonadotropin-releasing hormone receptor in stabilizing a high affinity ligand conformation
2. Ott, T. R., Troskie, B. E., Roeske, R. W., Flanagan, C. A., Illing, N., Millar, R. P., Two Mutations in extracellular loop 2 of the human gonadotropin-releasing-hormone receptor confer agonist activity to an antagonist
3. Faurholm, B., Millar, R.P. and Katz, A.A. The genes coding for the Type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8 overlap in two genomic loci.
4. Conklin, D.C., Sellar, R., Ott, T.R. and Millar, R.P. Human ribonucleoprotein RBM8 overlaps in the antisense orientation with the Type II gonadotropin releasing hormone receptor. Submitted for publication
5. Everest, H.M., Hislop, J.N., Harding, T., Uney, J.B., Flynn, A., Millar, R.P. and McArdle, C.A. Signalling and anti-proliferative effects mediated by gonadotropin-releasing hormone receptors after expression in breast cancer cells using recombinant adenovirus.
6. Hislop, J.N., Everest, H.M., Flynn, A., Harding, T., Uney, J.B., Troskie, B.E., Millar, R.P and McArdle, C.A. Differential internalisation of mammalian and non-mammalian gonadotropin-releasing hormone receptors: uncoupling of dynamin-dependent internalisation from mitogen-activated protein kinase signalling.
7. Petry, R., Craik, D., Haaima, G., Fromme, B., Klump, H., Kiefer, W., Palm, D. and Millar, R. Secondary structure of the third extracellular loop responsible for ligand selectivity of a mammalian gonadotropin-releasing hormone receptor