Burden of Disease Research Unit
| Frequently
asked questions |
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What
are the top causes of death in South Africa?
The top twenty single underlying causes of death in South Africa are shown in Tables 1 and 2 and Figure 1 below from the Revised Burden of Disease estimates for the Comparative Risk Factor Assessment for South Africa, 2000 (pdf format 259 kb). The tables show the ranking for persons, males and females while in the figure these are ranked by the persons total. The largest single cause of death is HIV/AIDS accounting for 132990 (25.5%) deaths. This is at least five times greater than the next largest single cause of death. Ischaemic heart disease and stroke follow with about 6.5% of the deaths and tuberculosis and interpersonal violence are next in the ranking, each accounting for about 5.5% of deaths. Males have higher proportions of deaths due to homicide/violence, tuberculosis and road traffic accidents than females. Females have higher proportions of deaths due to HIV/AIDS, stroke, hypertensive heart diseases and diabetes mellitus. These estimates do differ from those of the Initial Burden of Disease estimates for South Africa, 2000 (pdf format 457 kb) which are shown in comparable Tables 3 and 4 and Figure 2. The main differences arise from revising the estimates to reflect the deaths in the calendar year of 2000 and not from the middle of 2000 to the middle of 2001, as well as revising down the estimate of injury deaths as a result of more recent empirical data. Despite the differences, the overall profile remains that of a quadruple burden which is dominated by HIV/AIDS but also has the conditions associated with under-development, chronic diseases and injuries.
Table 1: Numbers of deaths by cause for persons, males and females, South Africa 2000 -Revised
| Persons |
Males |
Females |
Rank |
Cause of death |
Deaths |
Rank |
Cause of death |
Deaths |
Rank |
Cause of death |
Deaths |
1 |
HIV/AIDS |
132990 |
1 |
HIV/AIDS |
64418 |
1 |
HIV/AIDS |
68572 |
2 |
Ischaemic heart disease |
34402 |
2 |
Interpersonal violence |
23041 |
2 |
Stroke |
20353 |
3 |
Stroke |
33866 |
3 |
Tuberculosis |
18721 |
3 |
Ischaemic heart disease |
16666 |
4 |
Tuberculosis |
28907 |
4 |
Ischaemic heart disease |
17736 |
4 |
Hypertensive disease |
11433 |
5 |
Interpersonal violence |
27563 |
5 |
Stroke |
13513 |
5 |
Lower respiratory infections |
11367 |
6 |
Lower respiratory infections |
22910 |
6 |
Lower respiratory infections |
11543 |
6 |
Tuberculosis |
10186 |
7 |
Hypertensive disease |
16648 |
7 |
Road traffic accidents |
11207 |
7 |
Diabetes mellitus |
8748 |
8 |
Diarrhoeal diseases |
16006 |
8 |
Diarrhoeal diseases |
8012 |
8 |
Diarrhoeal diseases |
7994 |
9 |
Road traffic accidents |
15993 |
9 |
Chronic obstructive pulmonary disease |
7862 |
9 |
Low birth weight |
5326 |
10 |
Diabetes mellitus |
13546 |
10 |
Low birth weight |
6270 |
10 |
Chronic obstructive pulmonary disease |
4905 |
11 |
Chronic obstructive pulmonary disease |
12768 |
11 |
Hypertensive disease |
5214 |
11 |
Road traffic accidents |
4785 |
12 |
Low birth weight |
11597 |
12 |
Diabetes mellitus |
4798 |
12 |
Interpersonal violence |
4521 |
13 |
Asthma |
7006 |
13 |
Trachea/ bronchi/ lung cancer |
4669 |
13 |
Cervix cancer |
3498 |
14 |
Trachea/ bronchi/ lung cancer |
6885 |
14 |
Suicide |
4194 |
14 |
Asthma |
3468 |
15 |
Nephritis/nephrosis |
6760 |
15 |
Oesophageal cancer |
3566 |
15 |
Nephritis/ nephrosis |
3461 |
16 |
Septicaemia |
6234 |
16 |
Asthma |
3538 |
16 |
Septicaemia |
3316 |
17 |
Oesophageal cancer |
5579 |
17 |
Cirrhosis of liver |
3399 |
17 |
Breast cancer |
3156 |
18 |
Protein-energy malnutrition |
5499 |
18 |
Nephritis/ nephrosis |
3299 |
18 |
Inflammatory heart disease |
2783 |
19 |
Suicide |
5461 |
19 |
Protein-energy malnutrition |
2989 |
19 |
Protein-energy malnutrition |
2510 |
20 |
Cirrhosis of liver |
5442 |
20 |
Septicaemia |
2919 |
20 |
Trachea/ bronchi/ lung cancer |
2510 |
|
All causes |
521082 |
|
All causes |
274084 |
|
All causes |
246998 |
Table 2: Percentage of deaths by cause for persons, males and females, South Africa, 2000 - Revised
| Persons |
Males |
Females |
Rank |
Cause of death |
% |
Rank |
Cause of death |
% |
Rank |
Cause of death |
% |
1 |
HIV/AIDS |
25.5 |
1 |
HIV/AIDS |
23.5 |
1 |
HIV/AIDS |
27.8 |
2 |
Ischaemic heart disease |
6.6 |
2 |
Interpersonal violence |
8.4 |
2 |
Stroke |
8.2 |
3 |
Stroke |
6.5 |
3 |
Tuberculosis |
6.8 |
3 |
Ischaemic heart disease |
6.7 |
4 |
Tuberculosis |
5.5 |
4 |
Ischaemic heart disease |
6.5 |
4 |
Hypertensive disease |
4.6 |
5 |
Interpersonal violence |
5.3 |
5 |
Stroke |
4.9 |
5 |
Lower respiratory infections |
4.6 |
6 |
Lower respiratory infections |
4.4 |
6 |
Lower respiratory infections |
4.2 |
6 |
Tuberculosis |
4.1 |
7 |
Hypertensive disease |
3.2 |
7 |
Road traffic accidents |
4.1 |
7 |
Diabetes mellitus |
3.5 |
8 |
Diarrhoeal diseases |
3.1 |
8 |
Diarrhoeal diseases |
2.9 |
8 |
Diarrhoeal diseases |
3.2 |
9 |
Road traffic accidents |
3.1 |
9 |
Chronic obstructive pulmonary disease |
2.9 |
9 |
Low birth weight |
2.2 |
10 |
Diabetes mellitus |
2.6 |
10 |
Low birth weight |
2.3 |
10 |
Chronic obstructive pulmonary disease |
2.0 |
11 |
Chronic obstructive pulmonary disease |
2.5 |
11 |
Hypertensive disease |
1.9 |
11 |
Road traffic accidents |
1.9 |
12 |
Low birth weight |
2.2 |
12 |
Diabetes mellitus |
1.8 |
12 |
Interpersonal violence |
1.8 |
13 |
Asthma |
1.3 |
13 |
Trachea/ bronchi/ lung cancer |
1.7 |
13 |
Cervix cancer |
1.4 |
14 |
Trachea/ bronchi/ lung cancer |
1.3 |
14 |
Suicide |
1.5 |
14 |
Asthma |
1.4 |
15 |
Nephritis/nephrosis |
1.3 |
15 |
Oesophageal cancer |
1.3 |
15 |
Nephritis/ nephrosis |
1.4 |
16 |
Septicaemia |
1.2 |
16 |
Asthma |
1.3 |
16 |
Septicaemia |
1.3 |
17 |
Oesophageal cancer |
1.1 |
17 |
Cirrhosis of liver |
1.2 |
17 |
Breast cancer |
1.3 |
18 |
Protein-energy malnutrition |
1.1 |
18 |
Nephritis/ nephrosis |
1.2 |
18 |
Inflammatory heart disease |
1.1 |
19 |
Suicide |
1.0 |
19 |
Protein-energy malnutrition |
1.1 |
19 |
Protein-energy malnutrition |
1.0 |
20 |
Cirrhosis of liver |
1.0 |
20 |
Septicaemia |
1.1 |
20 |
Trachea/ bronchi/ lung cancer |
1.0 |
|
All causes |
100 |
|
All causes |
100 |
|
All causes |
100 |
Figure 1 Leading causes of mortality, South Africa 2000 - Revised
Table
3: Numbers of deaths by cause for persons, males and females, South Africa
2000 (Initial Burden of Disease Study)
| Persons |
Males |
Females |
Rank |
Cause
of death |
Deaths |
Rank |
Cause
of death |
Deaths |
Rank |
Cause
of death |
Deaths |
1 |
HIV/AIDS |
165859 |
1 |
HIV/AIDS |
80089 |
1 |
HIV/AIDS |
85770 |
2 |
Ischaemic
heart disease |
32919 |
2 |
Homicide/
violence |
27134 |
2 |
Stroke |
18184 |
3 |
Homicide/
violence |
32485 |
3 |
Tuberculosis |
19806 |
3 |
Ischaemic
heart disease |
14539 |
4 |
Stroke |
32114 |
4 |
Ischaemic
heart disease |
18380 |
4 |
Lower
respiratory infections |
10430 |
5 |
Tuberculosis |
29553 |
5 |
Stroke |
13930 |
5 |
Tuberculosis |
9748 |
6 |
Lower
respiratory infections |
22097 |
6 |
Road
traffic accidents |
13076 |
6 |
Hypertensive
heart disease |
9458 |
7 |
Road
traffic accidents |
18446 |
7 |
Lower
respiratory infections |
11667 |
7 |
Diabetes
mellitus |
8081 |
8 |
Diarrhoeal
diseases |
15910 |
8 |
Diarrhoeal
diseases |
8150 |
8 |
Diarrhoeal
diseases |
7761 |
9 |
Hypertensive
heart disease |
14233 |
9 |
Chronic
obstructive pulmonary disease |
8102 |
9 |
Low
birth weight |
5427 |
10 |
Diabetes
mellitus |
13157 |
10 |
Low
birth weight |
6449 |
10 |
Road
traffic accidents |
5370 |
11 |
Chronic
obstructive pulmonary disease |
12473 |
11 |
Trachea/bronchi/
lung
cancer |
5085 |
11 |
Homicide/
violence |
5351 |
12 |
Low
birth weight |
11876 |
12 |
Diabetes
mellitus |
5076 |
12 |
Chronic
obstructive pulmonary disease |
4372 |
13 |
Nephritis/nephrosis |
7225 |
13 |
Suicide |
4866 |
13 |
Nephritis/
nephrosis |
3505 |
14 |
Trachea/bronchi/
lung
cancer |
7173 |
14 |
Hypertensive
heart disease |
4774 |
14 |
Cervix
cancer |
3424 |
15 |
Asthma |
6987 |
15 |
Oesophageal
cancer |
3886 |
15 |
Asthma |
3227 |
16 |
Suicide |
6370 |
16 |
Asthma |
3760 |
16 |
Septicaemia |
3057 |
17 |
Septicaemia |
6047 |
17 |
Nephritis/
nephrosis |
3720 |
17 |
Breast
cancer |
3009 |
18 |
Oesophageal
cancer |
5803 |
18 |
Cirrhosis
of liver |
3704 |
18 |
Inflammatory
heart disease |
2559 |
19 |
Cirrhosis
of liver |
5672 |
19 |
Protein-energy
malnutrition |
3039 |
19 |
Protein-energy
malnutrition |
2471 |
20 |
Protein-energy
malnutrition |
5511 |
20 |
Septicaemia |
2990 |
20 |
Trachea/bronchi/
lung cancer |
2088 |
|
All
causes |
556585 |
|
All
causes |
303081 |
|
All
causes |
253504 |
Table42: Percentage of deaths by cause for persons, males and females, South Africa,
2000 (Initial Burden of Disease Study)
| Persons |
Males |
Females |
| Rank |
Cause
of death |
% |
Rank |
Cause
of death |
% |
Rank |
Cause
of death |
% |
1 |
HIV/AIDS |
29.8 |
1 |
HIV/AIDS |
26.4 |
1 |
HIV/AIDS |
33.8 |
2 |
Ischaemic
heart disease |
5.9 |
2 |
Homicide/
violence |
9.0 |
2 |
Stroke |
7.2 |
3 |
Homicide/
violence |
5.8 |
3 |
Tuberculosis |
6.5 |
3 |
Ischaemic
heart disease |
5.7 |
4 |
Stroke |
5.8 |
4 |
Ischaemic
heart disease |
6.1 |
4 |
Lower
respiratory infections |
4.1 |
5 |
Tuberculosis |
5.3 |
5 |
Stroke |
4.6 |
5 |
Tuberculosis |
3.8 |
6 |
Lower
respiratory infections |
4.0 |
6 |
Road
traffic accidents |
4.3 |
6 |
Hypertensive
heart disease |
3.7 |
7 |
Road
traffic accidents |
3.3 |
7 |
Lower
respiratory infections |
3.8 |
7 |
Diabetes
mellitus |
3.2 |
8 |
Diarrhoeal
diseases |
2.9 |
8 |
Diarrhoeal
diseases |
2.7 |
8 |
Diarrhoeal
diseases |
3.1 |
9 |
Hypertensive
heart disease |
2.6 |
9 |
Chronic
obstructive pulmonary disease |
2.7 |
9 |
Low
birth weight |
2.1 |
10 |
Diabetes
mellitus |
2.4 |
10 |
Low
birth weight |
2.1 |
10 |
Road
traffic accidents |
2.1 |
11 |
Chronic
obstructive pulmonary disease |
2.2 |
11 |
Trachea/bronchi/
lung
cancer |
1.7 |
11 |
Homicide/
violence |
2.1 |
12 |
Low
birth weight |
2.1 |
12 |
Diabetes
mellitus |
1.7 |
12 |
Chronic
obstructive pulmonary disease |
1.7 |
13 |
Nephritis/
nephrosis |
1.3 |
13 |
Suicide |
1.6 |
13 |
Nephritis/
nephrosis |
1.4 |
14 |
Trachea/bronchi/
lung
cancer |
1.3 |
14 |
Hypertensive
heart disease |
1.6 |
14 |
Cervix
cancer |
1.4 |
15 |
Asthma |
1.3 |
15 |
Oesophageal
cancer |
1.3 |
15 |
Asthma |
1.3 |
16 |
Suicide |
1.1 |
16 |
Asthma |
1.2 |
16 |
Septicaemia |
1.2 |
17 |
Septicaemia |
1.1 |
17 |
Nephritis/
nephrosis |
1.2 |
17 |
Breast
cancer |
1.2 |
18 |
Oesophageal
cancer |
1.0 |
18 |
Cirrhosis
of liver |
1.2 |
18 |
Inflammatory
heart disease |
1.0 |
19 |
Cirrhosis
of liver |
1.0 |
19 |
Protein-energy
malnutrition |
1.0 |
19 |
Protein-energy
malnutrition |
1.0 |
20 |
Protein-energy
malnutrition |
1.0 |
20 |
Septicaemia |
1.0 |
20 |
Trachea/bronchi/
lung
cancer |
0.8 |
|
All
causes |
100 |
|
All
causes |
100 |
|
All
causes |
100 |
Figure
2 Leading causes of mortality, South Africa 2000 (Initial Burden of Disease Study)

Authors: Dr Rosana Norman, Prof Debbie Bradshaw, Michelle Schneider, Desiree Pieterse and Dr Pam Groenewald |